STRINGSTRING
ELOC ELOC PLP2 PLP2 MYD88 MYD88 SKP1 SKP1 IFNB1 IFNB1 TRAF5 TRAF5 TRIM32 TRIM32 CD4 CD4 TLR4 TLR4 TIRAP TIRAP TICAM2 TICAM2 IRAK2 IRAK2 TRADD TRADD IRAK4 IRAK4 NOD2 NOD2 TLR2 TLR2 TAB2 TAB2 IKBKG IKBKG RELB RELB TRAF6 TRAF6 FADD FADD CREBBP CREBBP TLR7 TLR7 IL1R1 IL1R1 TAB1 TAB1 TLR3 TLR3 LOC111771935 LOC111771935 ELOB ELOB ENDOU ENDOU TLR5 TLR5 NOD1 NOD1 TRAF3 TRAF3 IRAK1 IRAK1 TAB3 TAB3 CUL5 CUL5 MAVS MAVS PLP1 PLP1 CYLD CYLD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
PLP2Proteolipid protein 2. (232 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
IFNB1Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
TRIM32Tripartite motif containing 32. (653 aa)
CD4CD4 molecule. (460 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
TIRAPTIR domain containing adaptor protein. (234 aa)
TICAM2TIR domain-containing protein. (238 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (621 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
RELBRELB proto-oncogene, NF-kB subunit. (709 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (212 aa)
CREBBPCREB binding protein. (2442 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1054 aa)
IL1R1Interleukin 1 receptor type 1. (578 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (654 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
LOC111771935Toll-like receptor 4. (843 aa)
ELOBElongin B. (118 aa)
ENDOUEndonuclease, poly(U) specific. (413 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (867 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (993 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (805 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
CUL5Cullin 5; Belongs to the cullin family. (780 aa)
MAVSMitochondrial antiviral signaling protein. (597 aa)
PLP1Proteolipid protein 1. (396 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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