STRINGSTRING
IL6R IL6R NOTCH1 NOTCH1 IL22 IL22 IL17RA IL17RA ACTB ACTB DLL1 DLL1 DLL4 DLL4 LGR5 LGR5 EGF EGF SNAI2 SNAI2 CD4 CD4 IL4 IL4 MMUT MMUT CCL20 CCL20 RORC RORC TNF TNF ASCL2 ASCL2 IL17RD IL17RD CD3E CD3E FOXP3 FOXP3 CCR6 CCR6 STAT3 STAT3 BCL2 BCL2 IFNG IFNG CCL22 CCL22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6RInterleukin 6 receptor. (471 aa)
NOTCH1Notch receptor 1. (2581 aa)
IL22Interleukin-22-like protein. (189 aa)
IL17RAInterleukin 17 receptor A. (866 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
CD4CD4 molecule. (460 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
MMUTMethylmalonyl-CoA mutase. (750 aa)
CCL20C-C motif chemokine. (96 aa)
RORCRAR related orphan receptor C. (596 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
ASCL2BHLH domain-containing protein. (394 aa)
IL17RDInterleukin 17 receptor D. (742 aa)
CD3ECD3e molecule. (246 aa)
FOXP3Forkhead box P3. (452 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (374 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
BCL2BCL2 apoptosis regulator. (285 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
CCL22C-C motif chemokine ligand 22. (98 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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