(25 nodes) (2019) Discrimination Between Self and Non-Self-Nucleic Acids by the Innate Immune System. network (Equus caballus)

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Your Input:
	LOC100147174	Uncharacterized protein. (186 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	AIM2	Absent in melanoma 2. (352 aa)
	APOB	Apolipoprotein B. (4423 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
	EXO1	Exonuclease 1. (835 aa)
	MOV10	Mov10 RISC complex RNA helicase. (1066 aa)
	TLR1	Toll-like receptor. (756 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1054 aa)
	HMGB3	High mobility group box 3. (310 aa)
	CASP1	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (405 aa)
	TLR10	Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa)
	CGAS	Cyclic GMP-AMP synthase. (581 aa)
	IRF3	Interferon regulatory factor 3. (426 aa)
	RNASEL	Ribonuclease L. (722 aa)
	OASL	Uncharacterized protein. (514 aa)
	SAMHD1	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (670 aa)
	TLR8	Toll-like receptor 8; Belongs to the Toll-like receptor family. (1038 aa)
	HMGB1	High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (860 aa)
	IFNB1	Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
	ADAR	Adenosine deaminase RNA specific. (1171 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (236 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	AGO2	ENSECAP00000001885	ENSECAP00000005648	Adenosine deaminase RNA specific.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.457
ADAR	APOB	ENSECAP00000001885	ENSECAP00000036863	Adenosine deaminase RNA specific.	Apolipoprotein B.	0.431
ADAR	MOV10	ENSECAP00000001885	ENSECAP00000027962	Adenosine deaminase RNA specific.	Mov10 RISC complex RNA helicase.	0.578
ADAR	RNASEL	ENSECAP00000001885	ENSECAP00000012986	Adenosine deaminase RNA specific.	Ribonuclease L.	0.592
ADAR	SAMHD1	ENSECAP00000001885	ENSECAP00000007322	Adenosine deaminase RNA specific.	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1.	0.562
AGO2	ADAR	ENSECAP00000005648	ENSECAP00000001885	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Adenosine deaminase RNA specific.	0.457
AGO2	EIF4E	ENSECAP00000005648	ENSECAP00000052494	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	0.689
AGO2	IRF3	ENSECAP00000005648	ENSECAP00000015946	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Interferon regulatory factor 3.	0.428
AGO2	MOV10	ENSECAP00000005648	ENSECAP00000027962	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Mov10 RISC complex RNA helicase.	0.832
AGO2	RNASEL	ENSECAP00000005648	ENSECAP00000012986	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Ribonuclease L.	0.459
AIM2	CASP1	ENSECAP00000038286	ENSECAP00000021890	Absent in melanoma 2.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.988
AIM2	CGAS	ENSECAP00000038286	ENSECAP00000017247	Absent in melanoma 2.	Cyclic GMP-AMP synthase.	0.808
AIM2	IFNB1	ENSECAP00000038286	ENSECAP00000004620	Absent in melanoma 2.	Interferon beta; Has antiviral, antibacterial and anticancer activities.	0.557
AIM2	IL18	ENSECAP00000038286	ENSECAP00000040862	Absent in melanoma 2.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.802
AIM2	IL1B	ENSECAP00000038286	ENSECAP00000053627	Absent in melanoma 2.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells.	0.770
AIM2	IRF3	ENSECAP00000038286	ENSECAP00000015946	Absent in melanoma 2.	Interferon regulatory factor 3.	0.607
AIM2	MYD88	ENSECAP00000038286	ENSECAP00000001633	Absent in melanoma 2.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.554
AIM2	TLR1	ENSECAP00000038286	ENSECAP00000026625	Absent in melanoma 2.	Toll-like receptor.	0.491
AIM2	TLR3	ENSECAP00000038286	ENSECAP00000032318	Absent in melanoma 2.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.574
AIM2	TLR7	ENSECAP00000038286	ENSECAP00000024910	Absent in melanoma 2.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.499