(7 nodes) (2019) Inhibition of mitochondrial autophagy protects donor lungs for lung transplantation against ischaemia-reperfusion injury in rats via the mTOR pathway. network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F6Y457_HORSE	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ALB	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (620 aa)
	LAMP2	Lysosomal associated membrane protein 2. (446 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	BECN1	Beclin 1. (448 aa)
	PINK1	PTEN induced kinase 1. (585 aa)
	GAPDHS	Glyceraldehyde-3-phosphate dehydrogenase. (396 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	BECN1	ENSECAP00000041304	ENSECAP00000016069	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Beclin 1.	0.705
ALB	F6Y457_HORSE	ENSECAP00000041304	ENSECAP00000002648	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Glyceraldehyde-3-phosphate dehydrogenase.	0.896
ALB	GAPDH	ENSECAP00000041304	ENSECAP00000019665	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Glyceraldehyde-3-phosphate dehydrogenase.	0.965
ALB	GAPDHS	ENSECAP00000041304	ENSECAP00000003459	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Glyceraldehyde-3-phosphate dehydrogenase.	0.872
ALB	LAMP2	ENSECAP00000041304	ENSECAP00000025006	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Lysosomal associated membrane protein 2.	0.566
ALB	PINK1	ENSECAP00000041304	ENSECAP00000007281	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	PTEN induced kinase 1.	0.521
BECN1	ALB	ENSECAP00000016069	ENSECAP00000041304	Beclin 1.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.705
BECN1	F6Y457_HORSE	ENSECAP00000016069	ENSECAP00000002648	Beclin 1.	Glyceraldehyde-3-phosphate dehydrogenase.	0.554
BECN1	GAPDH	ENSECAP00000016069	ENSECAP00000019665	Beclin 1.	Glyceraldehyde-3-phosphate dehydrogenase.	0.792
BECN1	GAPDHS	ENSECAP00000016069	ENSECAP00000003459	Beclin 1.	Glyceraldehyde-3-phosphate dehydrogenase.	0.475
BECN1	LAMP2	ENSECAP00000016069	ENSECAP00000025006	Beclin 1.	Lysosomal associated membrane protein 2.	0.895
BECN1	PINK1	ENSECAP00000016069	ENSECAP00000007281	Beclin 1.	PTEN induced kinase 1.	0.991
F6Y457_HORSE	ALB	ENSECAP00000002648	ENSECAP00000041304	Glyceraldehyde-3-phosphate dehydrogenase.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.896
F6Y457_HORSE	BECN1	ENSECAP00000002648	ENSECAP00000016069	Glyceraldehyde-3-phosphate dehydrogenase.	Beclin 1.	0.554
F6Y457_HORSE	GAPDHS	ENSECAP00000002648	ENSECAP00000003459	Glyceraldehyde-3-phosphate dehydrogenase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.611
F6Y457_HORSE	PINK1	ENSECAP00000002648	ENSECAP00000007281	Glyceraldehyde-3-phosphate dehydrogenase.	PTEN induced kinase 1.	0.479
GAPDH	ALB	ENSECAP00000019665	ENSECAP00000041304	Glyceraldehyde-3-phosphate dehydrogenase.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.965
GAPDH	BECN1	ENSECAP00000019665	ENSECAP00000016069	Glyceraldehyde-3-phosphate dehydrogenase.	Beclin 1.	0.792
GAPDH	GAPDHS	ENSECAP00000019665	ENSECAP00000003459	Glyceraldehyde-3-phosphate dehydrogenase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.959
GAPDH	LAMP2	ENSECAP00000019665	ENSECAP00000025006	Glyceraldehyde-3-phosphate dehydrogenase.	Lysosomal associated membrane protein 2.	0.583