STRINGSTRING
TLR10 TLR10 TRAF6 TRAF6 NOX3 NOX3 IDO2 IDO2 NOS3 NOS3 CCL5 CCL5 NOS2 NOS2 TLR7 TLR7 IDO1 IDO1 TLR1 TLR1 TSLP TSLP IFNG IFNG TLR3 TLR3 CD80 CD80 LOC111771935 LOC111771935 CCL1 CCL1 TRAF3 TRAF3 IL1B IL1B IL33 IL33 IL37 IL37 CCL3 CCL3 IRF7 IRF7 IRAK1 IRAK1 CD86 CD86 IL17A IL17A TLR5 TLR5 ICAM1 ICAM1 BCL2 BCL2 EGFR EGFR LOC102149380 LOC102149380 TLR6 TLR6 TNF TNF MYD88 MYD88 IFNB1 IFNB1 IL4 IL4 HMGB1 HMGB1 TLR8 TLR8 IL10 IL10 CD4 CD4 IL13 IL13 TLR4 TLR4 CFTR CFTR TIRAP TIRAP FGF2 FGF2 IRAK4 IRAK4 RNASEL RNASEL NLRP3 NLRP3 IL6 IL6 IL5 IL5 CD40 CD40 NOD2 NOD2 TLR2 TLR2 IRF3 IRF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR10Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
NOX3NADPH oxidase 3. (568 aa)
IDO2Indoleamine 2,3-dioxygenase 2. (420 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1267 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1247 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1054 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (434 aa)
TLR1Toll-like receptor. (756 aa)
TSLPThymic stromal lymphopoetin. (143 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
CD80CD80 molecule. (305 aa)
LOC111771935Toll-like receptor 4. (843 aa)
CCL1SCY domain-containing protein. (94 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
IL33Interleukin 33. (235 aa)
IL37Interleukin-1. (218 aa)
CCL3SCY domain-containing protein. (226 aa)
IRF7Interferon regulatory factor 7. (536 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (805 aa)
CD86CD86 molecule. (335 aa)
IL17AUncharacterized protein. (155 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (867 aa)
ICAM1Intercellular adhesion molecule 1. (628 aa)
BCL2BCL2 apoptosis regulator. (285 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
LOC102149380SERPIN domain-containing protein; Belongs to the serpin family. (385 aa)
TLR6Toll-like receptor. (859 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
IFNB1Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1038 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
CD4CD4 molecule. (460 aa)
IL13Interleukin-13. (133 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1541 aa)
TIRAPTIR domain containing adaptor protein. (234 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
RNASELRibonuclease L. (722 aa)
NLRP3NLR family pyrin domain containing 3. (1031 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
IRF3Interferon regulatory factor 3. (426 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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