STRINGSTRING
CDK2 CDK2 ARPC1B ARPC1B CD40LG CD40LG FOXO1 FOXO1 LIG4 LIG4 CTLA4 CTLA4 CBL CBL IL4 IL4 ADA ADA CD4 CD4 FOXN1 FOXN1 CYBA CYBA LOC111769802 LOC111769802 ZAP70 ZAP70 IL21 IL21 CD40 CD40 JAK1 JAK1 IL22 IL22 IL7 IL7 LAT LAT ROCK1 ROCK1 RAG1 RAG1 RAG2 RAG2 STAT2 STAT2 LCK LCK AK2 AK2 PGM3 PGM3 DCLRE1C DCLRE1C CD19 CD19 CORO1A CORO1A DOCK2 DOCK2 LRBA LRBA IL9 IL9 XIAP XIAP IL15 IL15 DOCK8 DOCK8 IL7R IL7R STK4 STK4 STAT1 STAT1 CD80 CD80 RHOH RHOH ITK ITK FOXP3 FOXP3 LOC111769795 LOC111769795 STAT3 STAT3 CD52 CD52 IL17A IL17A CD86 CD86 JAK3 JAK3 GATA2 GATA2 CD28 CD28
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
ARPC1BActin related protein 2/3 complex subunit 1B. (437 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
FOXO1Forkhead box O1. (651 aa)
LIG4DNA ligase. (911 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
CBLCbl proto-oncogene. (914 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
ADAAdenosine deaminase. (363 aa)
CD4CD4 molecule. (460 aa)
FOXN1Forkhead box N1. (646 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
LOC111769802Interleukin-7 receptor subunit alpha; Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP) (By similarity); Belongs to the type I cytokine receptor family. Type 4 subfamily. (458 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (158 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
JAK1Tyrosine-protein kinase. (1141 aa)
IL22Interleukin-22-like protein. (189 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (176 aa)
LATLinker for activation of T cells. (238 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1042 aa)
RAG2Recombination activating 2. (527 aa)
STAT2Signal transducer and activator of transcription. (847 aa)
LCKTyrosine-protein kinase. (509 aa)
AK2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (234 aa)
PGM3Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family. (570 aa)
DCLRE1CDNA cross-link repair 1C. (693 aa)
CD19CD19 molecule. (559 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1828 aa)
LRBALPS responsive beige-like anchor protein. (2852 aa)
IL9Interleukin 9. (147 aa)
XIAPX-linked inhibitor of apoptosis. (494 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (432 aa)
DOCK8Dedicator of cytokinesis 8; Belongs to the DOCK family. (2102 aa)
IL7RInterleukin 7 receptor. (458 aa)
STK4Serine/threonine kinase 4. (493 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
CD80CD80 molecule. (305 aa)
RHOHRas homolog family member H. (191 aa)
ITKTyrosine-protein kinase. (620 aa)
FOXP3Forkhead box P3. (452 aa)
LOC111769795Interleukin-7 receptor subunit alpha. (458 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CD52CD52 molecule. (65 aa)
IL17AUncharacterized protein. (155 aa)
CD86CD86 molecule. (335 aa)
JAK3Tyrosine-protein kinase. (1139 aa)
GATA2GATA binding protein 2. (625 aa)
CD28CD28 molecule. (228 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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