STRINGSTRING
TIRAP TIRAP TLR4 TLR4 CD4 CD4 HKDC1 HKDC1 NAIP NAIP MYD88 MYD88 TLR6 TLR6 IL1B IL1B AQP9 AQP9 HK1 HK1 NOD1 NOD1 ALPK1 ALPK1 TLR5 TLR5 STAT3 STAT3 LOC111771935 LOC111771935 CD36 CD36 TLR1 TLR1 HK2 HK2 TLR2 TLR2 NOD2 NOD2 HK3 HK3 LBP LBP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TIRAPTIR domain containing adaptor protein. (234 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
CD4CD4 molecule. (460 aa)
HKDC1Hexokinase domain containing 1. (922 aa)
NAIPNLR family apoptosis inhibitory protein. (1402 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TLR6Toll-like receptor. (859 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
AQP9Aquaporin 9; Belongs to the MIP/aquaporin (TC 1.A.8) family. (300 aa)
HK1Hexokinase 1. (944 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (993 aa)
ALPK1Alpha kinase 1. (1244 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (867 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
LOC111771935Toll-like receptor 4. (843 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
TLR1Toll-like receptor. (756 aa)
HK2Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. Belongs to the hexokinase family. (917 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
HK3Hexokinase 3. (924 aa)
LBPLipopolysaccharide binding protein. (481 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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