(36 nodes) (2020) Aged Tendon StemProgenitor Cells Are Less Competent to Form 3D Tendon Organoids Due to Cell Autonomous and Matrix Production Deficits. network (Equus caballus)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	IBSP	Integrin binding sialoprotein. (310 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
	TGM2	Transglutaminase 2. (687 aa)
	EGR2	Early growth response 2. (486 aa)
	NANOG	Homeobox domain-containing protein. (310 aa)
	CNN1	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (375 aa)
	MYOG	Myogenin. (224 aa)
	CCN2	Cellular communication network factor 2. (475 aa)
	HPRT1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (224 aa)
	LUM	Lumican. (341 aa)
	TNMD	Tenomodulin. (317 aa)
	SP7	Sp7 transcription factor. (431 aa)
	DCN	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa)
	COL15A1	Collagen type XV alpha 1 chain. (1388 aa)
	THBS2	Thrombospondin 2. (1172 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	SIX1	SIX homeobox 1. (284 aa)
	PLOD1	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. (727 aa)
	CD19	CD19 molecule. (559 aa)
	COL3A1	Collagen type III alpha 1 chain. (1466 aa)
	CD34	CD34 molecule. (379 aa)
	COL6A1	Collagen type VI alpha 1 chain. (1027 aa)
	FMOD	Fibromodulin. (392 aa)
	CD44	CD44 antigen. (700 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
	COMP	Cartilage oligomeric matrix protein. (793 aa)
	SPARC	Secreted protein acidic and cysteine rich. (313 aa)
	ACAN	Aggrecan. (2703 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (471 aa)
	ALB	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (620 aa)
	BGN	Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (460 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
	COL2A1	Collagen type II alpha 1 chain. (1487 aa)
	COL5A1	Collagen type V alpha 1 chain. (1813 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	COL1A1	Collagen type I alpha 1 chain. (1521 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAN	ALB	ENSECAP00000038831	ENSECAP00000041304	Aggrecan.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.749
ACAN	BGN	ENSECAP00000038831	ENSECAP00000041347	Aggrecan.	Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.950
ACAN	CCN2	ENSECAP00000038831	ENSECAP00000014264	Aggrecan.	Cellular communication network factor 2.	0.544
ACAN	CD34	ENSECAP00000038831	ENSECAP00000022541	Aggrecan.	CD34 molecule.	0.653
ACAN	CD44	ENSECAP00000038831	ENSECAP00000031627	Aggrecan.	CD44 antigen.	0.740
ACAN	COL1A1	ENSECAP00000038831	ENSECAP00000054911	Aggrecan.	Collagen type I alpha 1 chain.	0.836
ACAN	COL2A1	ENSECAP00000038831	ENSECAP00000048092	Aggrecan.	Collagen type II alpha 1 chain.	0.975
ACAN	COL3A1	ENSECAP00000038831	ENSECAP00000022362	Aggrecan.	Collagen type III alpha 1 chain.	0.525
ACAN	COMP	ENSECAP00000038831	ENSECAP00000037770	Aggrecan.	Cartilage oligomeric matrix protein.	0.966
ACAN	DCN	ENSECAP00000038831	ENSECAP00000017861	Aggrecan.	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.955
ACAN	FMOD	ENSECAP00000038831	ENSECAP00000030032	Aggrecan.	Fibromodulin.	0.914
ACAN	GAPDH	ENSECAP00000038831	ENSECAP00000019665	Aggrecan.	Glyceraldehyde-3-phosphate dehydrogenase.	0.757
ACAN	IBSP	ENSECAP00000038831	ENSECAP00000021997	Aggrecan.	Integrin binding sialoprotein.	0.464
ACAN	LPL	ENSECAP00000038831	ENSECAP00000040468	Aggrecan.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.459
ACAN	LUM	ENSECAP00000038831	ENSECAP00000015833	Aggrecan.	Lumican.	0.865
ACAN	NANOG	ENSECAP00000038831	ENSECAP00000010460	Aggrecan.	Homeobox domain-containing protein.	0.463
ACAN	SP7	ENSECAP00000038831	ENSECAP00000017587	Aggrecan.	Sp7 transcription factor.	0.453
ACAN	SPARC	ENSECAP00000038831	ENSECAP00000038342	Aggrecan.	Secreted protein acidic and cysteine rich.	0.517
ACAN	TNMD	ENSECAP00000038831	ENSECAP00000016647	Aggrecan.	Tenomodulin.	0.686
ALB	ACAN	ENSECAP00000041304	ENSECAP00000038831	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Aggrecan.	0.749