(34 nodes) (2020) Infection of Mammals and Mosquitoes by Alphaviruses: Involvement of Cell Death. network (Equus caballus)

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	IRF7	Interferon regulatory factor 7. (536 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (347 aa)
	HRK	Activator of apoptosis harakiri; Promotes apoptosis. (91 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (632 aa)
	AIM2	Absent in melanoma 2. (352 aa)
	XIAP	X-linked inhibitor of apoptosis. (494 aa)
	NTN1	Netrin 1. (604 aa)
	NEO1	Neogenin 1. (1489 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1256 aa)
	CASP1	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (405 aa)
	BMF	Bcl2 modifying factor. (227 aa)
	CASP3	Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa)
	DIABLO	Diablo IAP-binding mitochondrial protein. (237 aa)
	MCL1	MCL1 apoptosis regulator, BCL2 family member. (350 aa)
	BECN1	Beclin 1. (448 aa)
	IRF3	Interferon regulatory factor 3. (426 aa)
	MLKL	Mixed lineage kinase domain like pseudokinase. (543 aa)
	LOC111768755	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (144 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (275 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	TRADD	TNFRSF1A associated via death domain. (312 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (561 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3. (513 aa)
	IFNB1	Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (464 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
	DCC	DCC netrin 1 receptor. (1447 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (475 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM2	CASP1	ENSECAP00000038286	ENSECAP00000021890	Absent in melanoma 2.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.988
AIM2	IFNB1	ENSECAP00000038286	ENSECAP00000004620	Absent in melanoma 2.	Interferon beta; Has antiviral, antibacterial and anticancer activities.	0.557
AIM2	IL18	ENSECAP00000038286	ENSECAP00000040862	Absent in melanoma 2.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.802
AIM2	IL1B	ENSECAP00000038286	ENSECAP00000053627	Absent in melanoma 2.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells.	0.770
AIM2	IRF3	ENSECAP00000038286	ENSECAP00000015946	Absent in melanoma 2.	Interferon regulatory factor 3.	0.607
AIM2	IRF7	ENSECAP00000038286	ENSECAP00000047371	Absent in melanoma 2.	Interferon regulatory factor 7.	0.478
AIM2	TNF	ENSECAP00000038286	ENSECAP00000001460	Absent in melanoma 2.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.473
APAF1	BMF	ENSECAP00000022364	ENSECAP00000020526	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl2 modifying factor.	0.490
APAF1	CASP1	ENSECAP00000022364	ENSECAP00000021890	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.806
APAF1	CASP3	ENSECAP00000022364	ENSECAP00000019797	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-3-like protein; Belongs to the peptidase C14A family.	0.997
APAF1	CASP6	ENSECAP00000022364	ENSECAP00000013268	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 6; Belongs to the peptidase C14A family.	0.886
APAF1	CASP7	ENSECAP00000022364	ENSECAP00000045690	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 7; Belongs to the peptidase C14A family.	0.909
APAF1	CASP8	ENSECAP00000022364	ENSECAP00000004066	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8; Belongs to the peptidase C14A family.	0.968
APAF1	CASP9	ENSECAP00000022364	ENSECAP00000039254	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	CYCS	ENSECAP00000022364	ENSECAP00000012031	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	DIABLO	ENSECAP00000022364	ENSECAP00000017797	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Diablo IAP-binding mitochondrial protein.	0.850
APAF1	HRK	ENSECAP00000022364	ENSECAP00000044999	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Activator of apoptosis harakiri; Promotes apoptosis.	0.455
APAF1	LOC111768755	ENSECAP00000022364	ENSECAP00000013761	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	MCL1	ENSECAP00000022364	ENSECAP00000016379	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	MCL1 apoptosis regulator, BCL2 family member.	0.768
APAF1	MLKL	ENSECAP00000022364	ENSECAP00000015164	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Mixed lineage kinase domain like pseudokinase.	0.446