8 items (Equus caballus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	PXDN	Peroxidasin. (1596 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
	TIRAP	TIR domain containing adaptor protein. (234 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	PAX7	Paired box 7. (505 aa)
	PXDNL	Peroxidasin like. (1243 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
	LOC111771935	Toll-like receptor 4. (843 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111771935	PXDNL	ENSECAP00000033420	ENSECAP00000020314	Toll-like receptor 4.	Peroxidasin like.	0.631
LOC111771935	TIRAP	ENSECAP00000033420	ENSECAP00000010139	Toll-like receptor 4.	TIR domain containing adaptor protein.	0.979
LOC111771935	TLR2	ENSECAP00000033420	ENSECAP00000015544	Toll-like receptor 4.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.873
LOC111771935	TLR4	ENSECAP00000033420	ENSECAP00000008292	Toll-like receptor 4.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.824
MTOR	PXDN	ENSECAP00000049618	ENSECAP00000040420	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Peroxidasin.	0.471
MTOR	PXDNL	ENSECAP00000049618	ENSECAP00000020314	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Peroxidasin like.	0.471
PAX7	PXDN	ENSECAP00000018061	ENSECAP00000040420	Paired box 7.	Peroxidasin.	0.552
PAX7	PXDNL	ENSECAP00000018061	ENSECAP00000020314	Paired box 7.	Peroxidasin like.	0.552
PXDN	MTOR	ENSECAP00000040420	ENSECAP00000049618	Peroxidasin.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.471
PXDN	PAX7	ENSECAP00000040420	ENSECAP00000018061	Peroxidasin.	Paired box 7.	0.552
PXDN	TLR2	ENSECAP00000040420	ENSECAP00000015544	Peroxidasin.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.483
PXDNL	LOC111771935	ENSECAP00000020314	ENSECAP00000033420	Peroxidasin like.	Toll-like receptor 4.	0.631
PXDNL	MTOR	ENSECAP00000020314	ENSECAP00000049618	Peroxidasin like.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.471
PXDNL	PAX7	ENSECAP00000020314	ENSECAP00000018061	Peroxidasin like.	Paired box 7.	0.552
PXDNL	TLR2	ENSECAP00000020314	ENSECAP00000015544	Peroxidasin like.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.592
PXDNL	TLR4	ENSECAP00000020314	ENSECAP00000008292	Peroxidasin like.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.626
TIRAP	LOC111771935	ENSECAP00000010139	ENSECAP00000033420	TIR domain containing adaptor protein.	Toll-like receptor 4.	0.979
TIRAP	TLR2	ENSECAP00000010139	ENSECAP00000015544	TIR domain containing adaptor protein.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.990
TIRAP	TLR4	ENSECAP00000010139	ENSECAP00000008292	TIR domain containing adaptor protein.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.997
TLR2	LOC111771935	ENSECAP00000015544	ENSECAP00000033420	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	Toll-like receptor 4.	0.873