(5 nodes) (2021) Sevoflurane Modulates AKT Isoforms in Triple Negative Breast Cancer Cells. An Experimental Study. network (Equus caballus)

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Your Input:
	AKT2	Non-specific serine/threonine protein kinase. (528 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT2	AKT3	ENSECAP00000006890	ENSECAP00000017503	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.903
AKT2	EGF	ENSECAP00000006890	ENSECAP00000009190	Non-specific serine/threonine protein kinase.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.498
AKT2	INS	ENSECAP00000006890	ENSECAP00000022114	Non-specific serine/threonine protein kinase.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.777
AKT2	MTOR	ENSECAP00000006890	ENSECAP00000049618	Non-specific serine/threonine protein kinase.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.970
AKT3	AKT2	ENSECAP00000017503	ENSECAP00000006890	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.903
AKT3	EGF	ENSECAP00000017503	ENSECAP00000009190	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.466
AKT3	INS	ENSECAP00000017503	ENSECAP00000022114	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.603
AKT3	MTOR	ENSECAP00000017503	ENSECAP00000049618	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.970
EGF	AKT2	ENSECAP00000009190	ENSECAP00000006890	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Non-specific serine/threonine protein kinase.	0.498
EGF	AKT3	ENSECAP00000009190	ENSECAP00000017503	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.466
EGF	INS	ENSECAP00000009190	ENSECAP00000022114	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.997
INS	AKT2	ENSECAP00000022114	ENSECAP00000006890	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Non-specific serine/threonine protein kinase.	0.777
INS	AKT3	ENSECAP00000022114	ENSECAP00000017503	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.603
INS	EGF	ENSECAP00000022114	ENSECAP00000009190	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.997
INS	MTOR	ENSECAP00000022114	ENSECAP00000049618	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.676
MTOR	AKT2	ENSECAP00000049618	ENSECAP00000006890	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Non-specific serine/threonine protein kinase.	0.970
MTOR	AKT3	ENSECAP00000049618	ENSECAP00000017503	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.970
MTOR	INS	ENSECAP00000049618	ENSECAP00000022114	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.676