STRINGSTRING
CDKN2A CDKN2A IL1B IL1B FDPS FDPS EIF4E EIF4E NFE2L2 NFE2L2 HMGCR HMGCR NR4A3 NR4A3 COQ2 COQ2 ACAA2 ACAA2 CD86 CD86 MAD1L1 MAD1L1 GABARAP GABARAP STAT3 STAT3 NFKB2 NFKB2 IGF1 IGF1 MVK MVK IFNG IFNG SIRT2 SIRT2 LARP1 LARP1 PDSS2 PDSS2 MAFB MAFB CTSS CTSS AREG AREG PDSS1 PDSS1 CDKN1A CDKN1A RELB RELB MEF2D MEF2D PIK3R1 PIK3R1 GGPS1 GGPS1 CSF1 CSF1 MFN2 MFN2 IL6 IL6 HADHA HADHA TREM2 TREM2 FGF2 FGF2 RELA RELA GATA1 GATA1 IL13 IL13 STAT6 STAT6 IL10 IL10 HMGCS1 HMGCS1 IL4 IL4 NR1D2 NR1D2 CREB3L2 CREB3L2 NFE2L1 NFE2L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN2ACyclin dependent kinase inhibitor 2A. (214 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
FDPSUncharacterized protein; Belongs to the FPP/GGPP synthase family. (420 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (605 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (901 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (641 aa)
COQ24-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (391 aa)
ACAA2Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (422 aa)
CD86CD86 molecule. (335 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (754 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
NFKB2Nuclear factor kappa B subunit 2. (1024 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (541 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
SIRT2Sirtuin 2. (462 aa)
LARP1La ribonucleoprotein domain family member 1. (1387 aa)
PDSS2Decaprenyl diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (410 aa)
MAFBMAF bZIP transcription factor B. (323 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (332 aa)
AREGAmphiregulin. (247 aa)
PDSS1Decaprenyl diphosphate synthase subunit 1; Belongs to the FPP/GGPP synthase family. (408 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
RELBRELB proto-oncogene, NF-kB subunit. (709 aa)
MEF2DMyocyte enhancer factor 2D. (517 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GGPS1Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (299 aa)
CSF1Colony stimulating factor 1. (630 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
HADHAHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (762 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (298 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
GATA1GATA binding protein 1. (486 aa)
IL13Interleukin-13. (133 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (591 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
NFE2L1Nuclear factor, erythroid 2 like 1. (779 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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