STRINGSTRING
PLG PLG CTSB CTSB CLTC CLTC CEBPB CEBPB PRPF40A PRPF40A HSPA5 HSPA5 CDKN1B CDKN1B PSMA6 PSMA6 RPL30 RPL30 TGFBI TGFBI PSMA2 PSMA2 TFPI2 TFPI2 ACTB ACTB MCM7 MCM7 FAS FAS GAST GAST ITGB4 ITGB4 TRIM28 TRIM28 GRB2 GRB2 CLIC1 CLIC1 LCN2 LCN2 STAT3 STAT3 EIF4A3 EIF4A3 ALB ALB MAF MAF FUBP1 FUBP1 CDK2 CDK2 GSTO1 GSTO1 CUL3 CUL3 TFPI TFPI CCK CCK PSMA1 PSMA1 PLAU PLAU CD81 CD81 F6W654_HORSE F6W654_HORSE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLGPlasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...] (817 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (384 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
PRPF40APre-mRNA processing factor 40 homolog A. (994 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Belongs to the heat shock protein 70 family. (654 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PSMA6Proteasome subunit alpha type. (251 aa)
RPL30Ribosomal protein L30. (115 aa)
TGFBITransforming growth factor beta induced. (683 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
TFPI2Tissue factor pathway inhibitor. (234 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
FASFas cell surface death receptor. (365 aa)
GASTBig gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. (107 aa)
ITGB4Integrin beta. (1805 aa)
TRIM28Tripartite motif containing 28. (821 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CLIC1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (241 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (421 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
EIF4A3Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (411 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (620 aa)
MAFMAF bZIP transcription factor; Belongs to the bZIP family. (429 aa)
FUBP1Far upstream element binding protein 1. (687 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (387 aa)
CUL3Cullin 3; Belongs to the cullin family. (772 aa)
TFPITissue factor pathway inhibitor. (348 aa)
CCKCholecystokinin. (224 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
PLAUPlasminogen activator, urokinase. (433 aa)
CD81Tetraspanin. (393 aa)
F6W654_HORSESuperoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (216 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (20%) [HD]