27 items (Equus caballus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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experimentally determined

Predicted Interactions

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Your Input:
	TLR6	Toll-like receptor. (859 aa)
	TRIM25	Tripartite motif containing 25. (643 aa)
	IRF7	Interferon regulatory factor 7. (536 aa)
	MAVS	Mitochondrial antiviral signaling protein. (597 aa)
	TRIM27	Tripartite motif containing 27. (536 aa)
	TLR5	Toll like receptor 5; Belongs to the Toll-like receptor family. (867 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
	LOC111771935	Toll-like receptor 4. (843 aa)
	TLR1	Toll-like receptor. (756 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1054 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	TANK	TRAF family member associated NFKB activator. (426 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (332 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	TRIM65	Tripartite motif containing 65. (517 aa)
	TLR10	Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa)
	CGAS	Cyclic GMP-AMP synthase. (581 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
	ACO1	Aconitase 1; Belongs to the aconitase/IPM isomerase family. (939 aa)
	TIRAP	TIR domain containing adaptor protein. (234 aa)
	LRR1	Leucine rich repeat protein 1. (413 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (561 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
	TLR8	Toll-like receptor 8; Belongs to the Toll-like receptor family. (1038 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CGAS	IFNAR1	ENSECAP00000017247	ENSECAP00000008392	Cyclic GMP-AMP synthase.	Interferon alpha and beta receptor subunit 1.	0.401
CGAS	IL1B	ENSECAP00000017247	ENSECAP00000053627	Cyclic GMP-AMP synthase.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells.	0.481
CGAS	IL6	ENSECAP00000017247	ENSECAP00000014219	Cyclic GMP-AMP synthase.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.472
CGAS	IRF7	ENSECAP00000017247	ENSECAP00000047371	Cyclic GMP-AMP synthase.	Interferon regulatory factor 7.	0.675
CGAS	LOC111771935	ENSECAP00000017247	ENSECAP00000033420	Cyclic GMP-AMP synthase.	Toll-like receptor 4.	0.470
CGAS	MAVS	ENSECAP00000017247	ENSECAP00000045434	Cyclic GMP-AMP synthase.	Mitochondrial antiviral signaling protein.	0.775
CGAS	MYD88	ENSECAP00000017247	ENSECAP00000001633	Cyclic GMP-AMP synthase.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.531
CGAS	TANK	ENSECAP00000017247	ENSECAP00000024309	Cyclic GMP-AMP synthase.	TRAF family member associated NFKB activator.	0.417
CGAS	TBK1	ENSECAP00000017247	ENSECAP00000018587	Cyclic GMP-AMP synthase.	TANK binding kinase 1.	0.821
CGAS	TLR1	ENSECAP00000017247	ENSECAP00000026625	Cyclic GMP-AMP synthase.	Toll-like receptor.	0.483
CGAS	TLR2	ENSECAP00000017247	ENSECAP00000015544	Cyclic GMP-AMP synthase.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.521
CGAS	TLR4	ENSECAP00000017247	ENSECAP00000008292	Cyclic GMP-AMP synthase.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.471
CGAS	TLR6	ENSECAP00000017247	ENSECAP00000001398	Cyclic GMP-AMP synthase.	Toll-like receptor.	0.431
CGAS	TLR7	ENSECAP00000017247	ENSECAP00000024910	Cyclic GMP-AMP synthase.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.651
CGAS	TLR8	ENSECAP00000017247	ENSECAP00000007087	Cyclic GMP-AMP synthase.	Toll-like receptor 8; Belongs to the Toll-like receptor family.	0.476
CTSS	IL1B	ENSECAP00000020156	ENSECAP00000053627	Cathepsin S; Belongs to the peptidase C1 family.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells.	0.560
CTSS	IL6	ENSECAP00000020156	ENSECAP00000014219	Cathepsin S; Belongs to the peptidase C1 family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.504
CTSS	LOC111771935	ENSECAP00000020156	ENSECAP00000033420	Cathepsin S; Belongs to the peptidase C1 family.	Toll-like receptor 4.	0.445
CTSS	TGFB2	ENSECAP00000020156	ENSECAP00000051244	Cathepsin S; Belongs to the peptidase C1 family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.468
CTSS	TLR4	ENSECAP00000020156	ENSECAP00000008292	Cathepsin S; Belongs to the peptidase C1 family.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.447