(22 nodes) (2022) Down-Regulation of C1GALT1 Enhances the Progression of Cholangiocarcinoma through Activation of AKTERK Signaling Pathways. network (Equus caballus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	BCL2	BCL2 apoptosis regulator. (285 aa)
	ABCG2	ATP binding cassette subfamily G member 2. (682 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
	ABCC3	ATP binding cassette subfamily C member 3. (1612 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	CDK4	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
	CASP1	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (405 aa)
	PXDNL	Peroxidasin like. (1243 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (408 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	MUC5AC	Mucin 5AC, oligomeric mucus/gel-forming. (1007 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
	ST6GALNAC1	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (598 aa)
	FGFR2	Fibroblast growth factor receptor. (887 aa)
	MUC1	Mucin 1, cell surface associated. (714 aa)
	ABCC1	ATP binding cassette subfamily C member 1. (1540 aa)
	BIRC5	Baculoviral IAP repeat containing 5. (226 aa)
	PXDN	Peroxidasin. (1596 aa)
	MUC4	Uncharacterized protein. (1173 aa)
	CCNB1	Cyclin B1; Belongs to the cyclin family. (423 aa)
	C1GALT1	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (375 aa)
	GALNT5	Polypeptide N-acetylgalactosaminyltransferase. (940 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC1	ABCC3	ENSECAP00000005390	ENSECAP00000029294	ATP binding cassette subfamily C member 1.	ATP binding cassette subfamily C member 3.	0.410
ABCC1	ABCG2	ENSECAP00000005390	ENSECAP00000036913	ATP binding cassette subfamily C member 1.	ATP binding cassette subfamily G member 2.	0.971
ABCC1	BCL2	ENSECAP00000005390	ENSECAP00000037719	ATP binding cassette subfamily C member 1.	BCL2 apoptosis regulator.	0.499
ABCC1	ST6GALNAC1	ENSECAP00000005390	ENSECAP00000008221	ATP binding cassette subfamily C member 1.	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family.	0.475
ABCC3	ABCC1	ENSECAP00000029294	ENSECAP00000005390	ATP binding cassette subfamily C member 3.	ATP binding cassette subfamily C member 1.	0.410
ABCC3	ABCG2	ENSECAP00000029294	ENSECAP00000036913	ATP binding cassette subfamily C member 3.	ATP binding cassette subfamily G member 2.	0.526
ABCC3	ST6GALNAC1	ENSECAP00000029294	ENSECAP00000008221	ATP binding cassette subfamily C member 3.	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family.	0.595
ABCG2	ABCC1	ENSECAP00000036913	ENSECAP00000005390	ATP binding cassette subfamily G member 2.	ATP binding cassette subfamily C member 1.	0.971
ABCG2	ABCC3	ENSECAP00000036913	ENSECAP00000029294	ATP binding cassette subfamily G member 2.	ATP binding cassette subfamily C member 3.	0.526
ABCG2	ACTB	ENSECAP00000036913	ENSECAP00000013637	ATP binding cassette subfamily G member 2.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.424
ABCG2	BCL2	ENSECAP00000036913	ENSECAP00000037719	ATP binding cassette subfamily G member 2.	BCL2 apoptosis regulator.	0.443
ABCG2	CCND1	ENSECAP00000036913	ENSECAP00000027720	ATP binding cassette subfamily G member 2.	Cyclin D1; Belongs to the cyclin family.	0.435
ABCG2	PXDN	ENSECAP00000036913	ENSECAP00000040420	ATP binding cassette subfamily G member 2.	Peroxidasin.	0.497
ABCG2	PXDNL	ENSECAP00000036913	ENSECAP00000020314	ATP binding cassette subfamily G member 2.	Peroxidasin like.	0.498
ABCG2	TP53	ENSECAP00000036913	ENSECAP00000032751	ATP binding cassette subfamily G member 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.483
ACTB	ABCG2	ENSECAP00000013637	ENSECAP00000036913	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	ATP binding cassette subfamily G member 2.	0.424
ACTB	BCL2	ENSECAP00000013637	ENSECAP00000037719	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	BCL2 apoptosis regulator.	0.906
ACTB	CASP1	ENSECAP00000013637	ENSECAP00000021890	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.689
ACTB	CCNB1	ENSECAP00000013637	ENSECAP00000013636	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Cyclin B1; Belongs to the cyclin family.	0.747
ACTB	CCND1	ENSECAP00000013637	ENSECAP00000027720	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Cyclin D1; Belongs to the cyclin family.	0.815