node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | EGF | ENSECAP00000013637 | ENSECAP00000009190 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | 0.882 |
ACTB | WNT3A | ENSECAP00000013637 | ENSECAP00000023570 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.418 |
CHGA | LGR5 | ENSECAP00000030274 | ENSECAP00000009813 | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. | Leucine rich repeat containing G protein-coupled receptor 5. | 0.829 |
CHGA | RSPO1 | ENSECAP00000030274 | ENSECAP00000030767 | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. | R-spondin 1. | 0.409 |
CHGA-2 | LGR5 | ENSECAP00000050456 | ENSECAP00000009813 | Chromogranin A. | Leucine rich repeat containing G protein-coupled receptor 5. | 0.833 |
CHGA-2 | RSPO1 | ENSECAP00000050456 | ENSECAP00000030767 | Chromogranin A. | R-spondin 1. | 0.412 |
EGF | ACTB | ENSECAP00000009190 | ENSECAP00000013637 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.882 |
EGF | LGR5 | ENSECAP00000009190 | ENSECAP00000009813 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Leucine rich repeat containing G protein-coupled receptor 5. | 0.627 |
EGF | NOG | ENSECAP00000009190 | ENSECAP00000043687 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. | 0.747 |
EGF | RSPO1 | ENSECAP00000009190 | ENSECAP00000030767 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | R-spondin 1. | 0.769 |
EGF | WNT3A | ENSECAP00000009190 | ENSECAP00000023570 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.713 |
LGR5 | CHGA | ENSECAP00000009813 | ENSECAP00000030274 | Leucine rich repeat containing G protein-coupled receptor 5. | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. | 0.829 |
LGR5 | CHGA-2 | ENSECAP00000009813 | ENSECAP00000050456 | Leucine rich repeat containing G protein-coupled receptor 5. | Chromogranin A. | 0.833 |
LGR5 | EGF | ENSECAP00000009813 | ENSECAP00000009190 | Leucine rich repeat containing G protein-coupled receptor 5. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | 0.627 |
LGR5 | NOG | ENSECAP00000009813 | ENSECAP00000043687 | Leucine rich repeat containing G protein-coupled receptor 5. | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. | 0.600 |
LGR5 | RSPO1 | ENSECAP00000009813 | ENSECAP00000030767 | Leucine rich repeat containing G protein-coupled receptor 5. | R-spondin 1. | 0.998 |
LGR5 | WNT3A | ENSECAP00000009813 | ENSECAP00000023570 | Leucine rich repeat containing G protein-coupled receptor 5. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.674 |
MAPK11 | MAPK12 | ENSECAP00000004442 | ENSECAP00000015310 | Mitogen-activated protein kinase. | Mitogen-activated protein kinase. | 0.569 |
MAPK11 | MAPK13 | ENSECAP00000004442 | ENSECAP00000041374 | Mitogen-activated protein kinase. | Mitogen-activated protein kinase. | 0.485 |
MAPK12 | MAPK11 | ENSECAP00000015310 | ENSECAP00000004442 | Mitogen-activated protein kinase. | Mitogen-activated protein kinase. | 0.569 |