STRINGSTRING
HRG HRG TMPRSS11D TMPRSS11D EFEMP1 EFEMP1 LOC100061763 LOC100061763 CFI CFI SERPINA6 SERPINA6 PGK1 PGK1 ACTB ACTB PIGR PIGR KRT4 KRT4 PGD PGD C1QB C1QB AHCY AHCY C1R C1R HABP2 HABP2 ARG1 ARG1 SERPINB5 SERPINB5 GLRX GLRX ENSECAP00000023676 ENSECAP00000023676 ENSECAP00000024968 ENSECAP00000024968 ENSECAP00000026490 ENSECAP00000026490 LOC100061598 LOC100061598 AHCYL2 AHCYL2 PLG PLG C8B C8B AHCYL1 AHCYL1 FGA FGA JCHAIN JCHAIN ENSECAP00000044466 ENSECAP00000044466 WDR1 WDR1 ZG16B ZG16B SPI2 SPI2 AHSG AHSG DNASE1 DNASE1 ADA ADA KRT15 KRT15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HRGHistidine rich glycoprotein. (483 aa)
TMPRSS11DTransmembrane protease serine; Belongs to the peptidase S1 family. (418 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (614 aa)
LOC100061763Uncharacterized protein. (1477 aa)
CFIUncharacterized protein; Belongs to the peptidase S1 family. (630 aa)
SERPINA6Serpin family A member 6; Belongs to the serpin family. (430 aa)
PGK1Phosphoglycerate kinase 1; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. (417 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
PIGRPolymeric immunoglobulin receptor. (862 aa)
KRT4IF rod domain-containing protein; Belongs to the intermediate filament family. (607 aa)
PGD6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (483 aa)
C1QBComplement C1q B chain. (252 aa)
AHCYAdenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (450 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (705 aa)
HABP2Hyaluronan binding protein 2. (611 aa)
ARG1Arginase. (348 aa)
SERPINB5Serpin family B member 5; Belongs to the serpin family. (375 aa)
GLRXGlutaredoxin. (107 aa)
ENSECAP00000023676Jacalin-type lectin domain-containing protein. (302 aa)
ENSECAP00000024968Jacalin-type lectin domain-containing protein. (219 aa)
ENSECAP00000026490Jacalin-type lectin domain-containing protein. (155 aa)
LOC100061598EF-hand domain-containing protein; Belongs to the S-100 family. (162 aa)
AHCYL2Adenosylhomocysteinase like 2; Belongs to the adenosylhomocysteinase family. (657 aa)
PLGPlasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...] (817 aa)
C8BComplement C8 beta chain. (590 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (691 aa)
FGAFibrinogen alpha chain. (975 aa)
JCHAINJoining chain of multimeric IgA and IgM. (191 aa)
ENSECAP00000044466Jacalin-type lectin domain-containing protein. (193 aa)
WDR1WD repeat domain 1. (695 aa)
ZG16BJacalin-type lectin domain-containing protein. (240 aa)
SPI2Alpha-1-antiproteinase 2; Inhibitor of serine proteases. (454 aa)
AHSGAlpha 2-HS glycoprotein. (398 aa)
DNASE1Deoxyribonuclease-1; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (By similarity). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intra [...] (282 aa)
ADAAdenosine deaminase. (363 aa)
KRT15Keratin 13; Belongs to the intermediate filament family. (522 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.