STRINGSTRING
SLC12A2 SLC12A2 GAS6 GAS6 CCR2 CCR2 SOCS3 SOCS3 TNF TNF XCR1 XCR1 RABIF RABIF ADAM9 ADAM9 PANX1 PANX1 APOE APOE ADAM10 ADAM10 CALR CALR IL10 IL10 CD4 CD4 THBS1 THBS1 APOA1 APOA1 JAK2 JAK2 EGF EGF AXL AXL MMP9 MMP9 GSDMD GSDMD LOC100062428 LOC100062428 STAB2 STAB2 PLSCR3 PLSCR3 SLC66A1 SLC66A1 ANXA1 ANXA1 IL6 IL6 ARG2 ARG2 PLSCR1 PLSCR1 MLKL MLKL TYRO3 TYRO3 PLSCR5 PLSCR5 SCARF1 SCARF1 ROCK1 ROCK1 CASP3 CASP3 MAP1A MAP1A ODC1 ODC1 ARG1 ARG1 MERTK MERTK CASP1 CASP1 SOCS1 SOCS1 DNASE1L3 DNASE1L3 RICTOR RICTOR NR4A1 NR4A1 CD47 CD47 NR4A2 NR4A2 SIRT1 SIRT1 CD36 CD36 TP53 TP53 PBX1 PBX1 ADAM17 ADAM17 STAT3 STAT3 RHOA RHOA EPO EPO SLC16A1 SLC16A1 IL18 IL18 ABCA1 ABCA1 ELMO1 ELMO1 SGK1 SGK1 FLT3 FLT3 IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC12A2Solute carrier family 12 member 2. (1208 aa)
GAS6Growth arrest specific 6. (646 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (380 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
RABIFRAB interacting factor. (123 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (428 aa)
APOEApolipoprotein E. (310 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
CALRCalreticulin. (412 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
CD4CD4 molecule. (460 aa)
THBS1Thrombospondin 1. (1170 aa)
APOA1Apolipoprotein A1. (266 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
MMP9Matrix metallopeptidase 9. (714 aa)
GSDMDGasdermin D. (485 aa)
LOC100062428Calreticulin. (408 aa)
STAB2Stabilin 2. (2549 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa)
SLC66A1Solute carrier family 66 member 1. (291 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
ARG2Arginase. (351 aa)
PLSCR1Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (336 aa)
MLKLMixed lineage kinase domain like pseudokinase. (543 aa)
TYRO3TYRO3 protein tyrosine kinase. (1036 aa)
PLSCR5Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (277 aa)
SCARF1Scavenger receptor class F member 1. (830 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
CASP3Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa)
MAP1AMicrotubule associated protein 1A. (3073 aa)
ODC1Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (489 aa)
ARG1Arginase. (348 aa)
MERTKMER proto-oncogene, tyrosine kinase. (993 aa)
CASP1Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (405 aa)
SOCS1Suppressor of cytokine signaling 1. (222 aa)
DNASE1L3Deoxyribonuclease; Belongs to the DNase I family. (311 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (852 aa)
CD47CD47 molecule. (334 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (609 aa)
SIRT1Sirtuin 1. (737 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
PBX1PBX homeobox 1. (430 aa)
ADAM17ADAM metallopeptidase domain 17. (891 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
RHOATransforming protein RhoA-like protein. (193 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
SLC16A1Solute carrier family 16 member 1. (571 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ABCA1ATP binding cassette subfamily A member 1. (2304 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1020 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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