STRINGSTRING
ADM ADM CCK CCK GCG GCG CCL3 CCL3 ARRB2 ARRB2 IL18 IL18 CD86 CD86 PRKACB PRKACB CASP9 CASP9 VEGFC VEGFC ICAM1 ICAM1 PPY PPY CRH CRH BDNF BDNF EGFR EGFR LEP LEP IGF1 IGF1 CD80 CD80 VEGFD VEGFD GUCY2D GUCY2D PRKACA PRKACA IFNG IFNG RAB7A RAB7A TLR1 TLR1 ARRB1 ARRB1 GALP GALP CD34 CD34 CCL5 CCL5 CREBBP CREBBP INS INS LOC100064777 LOC100064777 CCL2 CCL2 PRCP PRCP SST SST SHH SHH CASP3 CASP3 SSTR2 SSTR2 ADM2 ADM2 CRHR1 CRHR1 GUCY2C GUCY2C ECE1 ECE1 IL5 IL5 IL6 IL6 FASLG FASLG GAL GAL NPY5R NPY5R ESCO1 ESCO1 PYY PYY FGF2 FGF2 ACE ACE GUCY2F GUCY2F ESCO2 ESCO2 SRC SRC NPR2 NPR2 NTS NTS NGF NGF SCT SCT MEIS1 MEIS1 CPE CPE CD4 CD4 IL10 IL10 NPY NPY TBP TBP AQP5 AQP5 NR2F2 NR2F2 RAMP2 RAMP2 SSTR3 SSTR3 SSTR5 SSTR5 SSTR1 SSTR1 NPY2R NPY2R CALCR CALCR TAC1 TAC1 ACE2 ACE2 TLR6 TLR6 SOCS3 SOCS3 NPR1 NPR1 KITLG KITLG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADMAdrenomedullin. (309 aa)
CCKCholecystokinin. (224 aa)
GCGGlucagon. (232 aa)
CCL3SCY domain-containing protein. (226 aa)
ARRB2Arrestin beta 2. (409 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CD86CD86 molecule. (335 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (632 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
ICAM1Intercellular adhesion molecule 1. (628 aa)
PPYPancreatic polypeptide; Belongs to the NPY family. (104 aa)
CRHCorticotropin releasing hormone. (232 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (299 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
CD80CD80 molecule. (305 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
GUCY2DGuanylate cyclase. (1111 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
RAB7ARAB7A, member RAS oncogene family. (229 aa)
TLR1Toll-like receptor. (756 aa)
ARRB1Arrestin beta 1. (642 aa)
GALPGalanin like peptide. (115 aa)
CD34CD34 molecule. (379 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
CREBBPCREB binding protein. (2442 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LOC100064777Angiotensin-converting enzyme. (619 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
PRCPProlylcarboxypeptidase. (497 aa)
SSTSomatostatin. (116 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
CASP3Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
ADM2Adrenomedullin 2. (142 aa)
CRHR1Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (415 aa)
GUCY2CGuanylate cyclase. (1070 aa)
ECE1Endothelin converting enzyme 1. (779 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (283 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
NPY5RNeuropeptide Y receptor Y5. (459 aa)
ESCO1Establishment of sister chromatid cohesion N-acetyltransferase 1. (847 aa)
PYYPeptide YY. (252 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
ACEAngiotensin-converting enzyme. (1313 aa)
GUCY2FGuanylate cyclase. (1108 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (623 aa)
SRCTyrosine-protein kinase. (551 aa)
NPR2Guanylate cyclase. (1065 aa)
NTSNeurotensin. (170 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)
SCTGLUCAGON domain-containing protein. (57 aa)
MEIS1Meis homeobox 1. (465 aa)
CPECarboxypeptidase E. (476 aa)
CD4CD4 molecule. (460 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
NPYNeuropeptide Y. (157 aa)
TBPTATA-box binding protein. (329 aa)
AQP5Aquaporin 5; Belongs to the MIP/aquaporin (TC 1.A.8) family. (400 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (643 aa)
RAMP2Receptor activity modifying protein 2. (181 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (420 aa)
SSTR5Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (365 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (390 aa)
NPY2RNeuropeptide Y receptor Y2; Belongs to the G-protein coupled receptor 1 family. (381 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (475 aa)
TAC1Substance P. (130 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
TLR6Toll-like receptor. (859 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
NPR1Guanylate cyclase. (1058 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (303 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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