(11 nodes) (2022) MET Oncogene Controls Invasive Growth by Coupling with NMDA Receptor. network (Equus caballus)

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Your Input:
	PGR	Progesterone receptor. (934 aa)
	SRC	Tyrosine-protein kinase. (551 aa)
	HCLS1	Hematopoietic cell-specific Lyn substrate 1. (498 aa)
	EZR	Ezrin. (830 aa)
	ESR1	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (608 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	PXN	Paxillin. (1236 aa)
	GRIN3B	Glutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1044 aa)
	CTTN	Cortactin. (559 aa)
	FYN	Tyrosine-protein kinase. (589 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTTN	ESR1	ENSECAP00000045577	ENSECAP00000020141	Cortactin.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.430
CTTN	EZR	ENSECAP00000045577	ENSECAP00000016264	Cortactin.	Ezrin.	0.629
CTTN	FYN	ENSECAP00000045577	ENSECAP00000047786	Cortactin.	Tyrosine-protein kinase.	0.611
CTTN	HCLS1	ENSECAP00000045577	ENSECAP00000013412	Cortactin.	Hematopoietic cell-specific Lyn substrate 1.	0.922
CTTN	PXN	ENSECAP00000045577	ENSECAP00000043492	Cortactin.	Paxillin.	0.927
CTTN	SRC	ENSECAP00000045577	ENSECAP00000010024	Cortactin.	Tyrosine-protein kinase.	0.991
ESR1	CTTN	ENSECAP00000020141	ENSECAP00000045577	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Cortactin.	0.430
ESR1	FYN	ENSECAP00000020141	ENSECAP00000047786	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Tyrosine-protein kinase.	0.410
ESR1	HCLS1	ENSECAP00000020141	ENSECAP00000013412	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Hematopoietic cell-specific Lyn substrate 1.	0.430
ESR1	INS	ENSECAP00000020141	ENSECAP00000022114	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.905
ESR1	PGR	ENSECAP00000020141	ENSECAP00000009675	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Progesterone receptor.	0.977
ESR1	SRC	ENSECAP00000020141	ENSECAP00000010024	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Tyrosine-protein kinase.	0.998
EZR	CTTN	ENSECAP00000016264	ENSECAP00000045577	Ezrin.	Cortactin.	0.629
EZR	HCLS1	ENSECAP00000016264	ENSECAP00000013412	Ezrin.	Hematopoietic cell-specific Lyn substrate 1.	0.628
EZR	PXN	ENSECAP00000016264	ENSECAP00000043492	Ezrin.	Paxillin.	0.828
EZR	SRC	ENSECAP00000016264	ENSECAP00000010024	Ezrin.	Tyrosine-protein kinase.	0.675
FYN	CTTN	ENSECAP00000047786	ENSECAP00000045577	Tyrosine-protein kinase.	Cortactin.	0.611
FYN	ESR1	ENSECAP00000047786	ENSECAP00000020141	Tyrosine-protein kinase.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.410
FYN	HCLS1	ENSECAP00000047786	ENSECAP00000013412	Tyrosine-protein kinase.	Hematopoietic cell-specific Lyn substrate 1.	0.603
FYN	INS	ENSECAP00000047786	ENSECAP00000022114	Tyrosine-protein kinase.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.492