node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | CCNA1 | ENSECAP00000013637 | ENSECAP00000017104 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Cyclin A1; Belongs to the cyclin family. | 0.528 |
ACTB | CCND1 | ENSECAP00000013637 | ENSECAP00000027720 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Cyclin D1; Belongs to the cyclin family. | 0.815 |
ACTB | CCNE2 | ENSECAP00000013637 | ENSECAP00000018001 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Cyclin E2; Belongs to the cyclin family. | 0.519 |
ACTB | CDK1 | ENSECAP00000013637 | ENSECAP00000032498 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. | 0.519 |
ACTB | CDK2 | ENSECAP00000013637 | ENSECAP00000049140 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.687 |
ACTB | CDK4 | ENSECAP00000013637 | ENSECAP00000022611 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | 0.663 |
ACTB | E2F1 | ENSECAP00000013637 | ENSECAP00000021291 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | E2F transcription factor 1. | 0.529 |
ACTB | EGF | ENSECAP00000013637 | ENSECAP00000009190 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | 0.882 |
ACTB | GAPDH | ENSECAP00000013637 | ENSECAP00000019665 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Glyceraldehyde-3-phosphate dehydrogenase. | 0.967 |
ACTB | INS | ENSECAP00000013637 | ENSECAP00000022114 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.906 |
ACTB | SKP2 | ENSECAP00000013637 | ENSECAP00000011076 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | S-phase kinase associated protein 2. | 0.400 |
ACTB | TP53 | ENSECAP00000013637 | ENSECAP00000032751 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.895 |
CCNA1 | ACTB | ENSECAP00000017104 | ENSECAP00000013637 | Cyclin A1; Belongs to the cyclin family. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.528 |
CCNA1 | CCND1 | ENSECAP00000017104 | ENSECAP00000027720 | Cyclin A1; Belongs to the cyclin family. | Cyclin D1; Belongs to the cyclin family. | 0.509 |
CCNA1 | CCNE2 | ENSECAP00000017104 | ENSECAP00000018001 | Cyclin A1; Belongs to the cyclin family. | Cyclin E2; Belongs to the cyclin family. | 0.981 |
CCNA1 | CDC25A | ENSECAP00000017104 | ENSECAP00000027183 | Cyclin A1; Belongs to the cyclin family. | Cell division cycle 25A. | 0.939 |
CCNA1 | CDK1 | ENSECAP00000017104 | ENSECAP00000032498 | Cyclin A1; Belongs to the cyclin family. | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. | 0.999 |
CCNA1 | CDK2 | ENSECAP00000017104 | ENSECAP00000049140 | Cyclin A1; Belongs to the cyclin family. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.999 |
CCNA1 | CDK4 | ENSECAP00000017104 | ENSECAP00000022611 | Cyclin A1; Belongs to the cyclin family. | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | 0.979 |
CCNA1 | DHFR | ENSECAP00000017104 | ENSECAP00000022919 | Cyclin A1; Belongs to the cyclin family. | DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. | 0.487 |