STRINGSTRING
ALB ALB MAPK13 MAPK13 NR4A3 NR4A3 CCL22 CCL22 UPRT UPRT CHD3 CHD3 IRF8 IRF8 FLT3 FLT3 CSPG5 CSPG5 EGR1 EGR1 LOC111770212 LOC111770212 TNFAIP6 TNFAIP6 BATF3 BATF3 SMARCA4 SMARCA4 IL4 IL4 SMARCB1 SMARCB1 MAPK11 MAPK11 CCR7 CCR7 MYD88 MYD88 TLR6 TLR6 CD86 CD86 SMARCC2 SMARCC2 CX3CL1 CX3CL1 STAT3 STAT3 CD80 CD80 STAT1 STAT1 IFNG IFNG CCL24 CCL24 CTBP1 CTBP1 IRF4 IRF4 TLR1 TLR1 VCAM1 VCAM1 RUNX3 RUNX3 IPO8 IPO8 DHFR DHFR CD19 CD19 IL1A IL1A CTBP2 CTBP2 CHD4 CHD4 ZBTB46 ZBTB46 MAPK12 MAPK12 CD40 CD40 HDAC1 HDAC1 MAPK14 MAPK14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (620 aa)
MAPK13Mitogen-activated protein kinase. (421 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (641 aa)
CCL22C-C motif chemokine ligand 22. (98 aa)
UPRTUracil phosphoribosyltransferase homolog. (353 aa)
CHD3Chromodomain helicase DNA binding protein 3. (2056 aa)
IRF8Interferon regulatory factor 8. (492 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1020 aa)
CSPG5SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1681 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (654 aa)
LOC111770212C-C motif chemokine. (100 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (253 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1647 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (451 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TLR6Toll-like receptor. (859 aa)
CD86CD86 molecule. (335 aa)
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1244 aa)
CX3CL1SCY domain-containing protein. (561 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CD80CD80 molecule. (305 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
CCL24C-C motif chemokine ligand 24. (109 aa)
CTBP1C-terminal binding protein 1. (655 aa)
IRF4Interferon regulatory factor 4. (606 aa)
TLR1Toll-like receptor. (756 aa)
VCAM1Vascular cell adhesion molecule 1. (786 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (433 aa)
IPO8Importin 8. (1062 aa)
DHFRDHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
CD19CD19 molecule. (559 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
CTBP2C-terminal binding protein 2. (980 aa)
CHD4Chromodomain helicase DNA binding protein 4. (1912 aa)
ZBTB46Zinc finger and BTB domain containing 46. (590 aa)
MAPK12Mitogen-activated protein kinase. (365 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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