STRINGSTRING
ROCK1 ROCK1 TNF TNF HIST2H3C HIST2H3C LOC100053259 LOC100053259 F7DCC3_HORSE F7DCC3_HORSE LOC111774036 LOC111774036 CD4 CD4 PTTG1 PTTG1 JAK2 JAK2 CA9 CA9 CCNB1 CCNB1 IL6 IL6 PTEN PTEN CASP3 CASP3 ESR1 ESR1 CD19 CD19 CCND1 CCND1 G3BP1 G3BP1 SMAD2 SMAD2 TP53 TP53 STAT3 STAT3 BCL2 BCL2 SP1 SP1 IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
HIST2H3CHistone H3; Belongs to the histone H3 family. (136 aa)
LOC100053259Histone H3; Belongs to the histone H3 family. (136 aa)
F7DCC3_HORSEHistone H3; Belongs to the histone H3 family. (136 aa)
LOC111774036Histone H3; Belongs to the histone H3 family. (136 aa)
CD4CD4 molecule. (460 aa)
PTTG1Uncharacterized protein. (202 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
CA9Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family. (441 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (423 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
PTENPhosphatase and tensin homolog. (576 aa)
CASP3Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (608 aa)
CD19CD19 molecule. (559 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
G3BP1G3BP stress granule assembly factor 1. (508 aa)
SMAD2Mothers against decapentaplegic homolog. (610 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
BCL2BCL2 apoptosis regulator. (285 aa)
SP1Sp1 transcription factor. (787 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.