STRINGSTRING
ALB ALB PMAIP1 PMAIP1 VIM VIM STAT3 STAT3 LEP LEP TP53 TP53 CDK1 CDK1 SMAD4 SMAD4 KRAS KRAS JAK1 JAK1 HELLS HELLS IL6 IL6 CCNB1 CCNB1 CCNB2 CCNB2 PGR PGR JAK2 JAK2 SNAI1 SNAI1 BIRC5 BIRC5 CXCR4 CXCR4 TGFB2 TGFB2 CDKN2A CDKN2A RRM2 RRM2 MTOR MTOR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (620 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
VIMVimentin; Belongs to the intermediate filament family. (495 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (373 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
JAK1Tyrosine-protein kinase. (1141 aa)
HELLSHelicase, lymphoid specific. (838 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (423 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (378 aa)
PGRProgesterone receptor. (934 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
SNAI1Snail family transcriptional repressor 1. (265 aa)
BIRC5Baculoviral IAP repeat containing 5. (226 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (214 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (417 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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