STRINGSTRING
PRKACA PRKACA STAT4 STAT4 STAT2 STAT2 IGF1R IGF1R REN REN ITGB3 ITGB3 SPP1 SPP1 FSHR FSHR EGF EGF JAK2 JAK2 STAT6 STAT6 STAT3 STAT3 BDNF BDNF IGFBP2 IGFBP2 PRKACB PRKACB STAT5A STAT5A LEP LEP STAT5B STAT5B STAT1 STAT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
STAT2Signal transducer and activator of transcription. (847 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
RENRenin; Belongs to the peptidase A1 family. (407 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
SPP1Secreted phosphoprotein 1. (313 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (694 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (299 aa)
IGFBP2Insulin like growth factor binding protein 2. (326 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
STAT5ASignal transducer and activator of transcription. (800 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa)
STAT5BSignal transducer and activator of transcription. (825 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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