(16 nodes) (2022) Metabolomic exploration of the effects of habituation to livestock trailer and extended transportation in goats. network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
	GPX5	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (294 aa)
	PLD2	Phospholipase. (933 aa)
	ARG2	Arginase. (351 aa)
	GPX7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
	CPT2	Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (658 aa)
	CASP3	Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
	ARG1	Arginase. (348 aa)
	GPX4	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (199 aa)
	ENSECAP00000042890	Uncharacterized protein. (145 aa)
	PLD1	Phospholipase. (1189 aa)
	GPX3	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
	GPX2	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa)
	F6W654_HORSE	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (216 aa)
	GPX6	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (220 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARG1	ARG2	ENSECAP00000021081	ENSECAP00000014452	Arginase.	Arginase.	0.910
ARG1	IL6	ENSECAP00000021081	ENSECAP00000014219	Arginase.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.927
ARG2	ARG1	ENSECAP00000014452	ENSECAP00000021081	Arginase.	Arginase.	0.910
ARG2	IL6	ENSECAP00000014452	ENSECAP00000014219	Arginase.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.629
CASP3	ENSECAP00000042890	ENSECAP00000019797	ENSECAP00000042890	Caspase-3-like protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.678
CASP3	GPX2	ENSECAP00000019797	ENSECAP00000054731	Caspase-3-like protein; Belongs to the peptidase C14A family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.608
CASP3	GPX3	ENSECAP00000019797	ENSECAP00000051326	Caspase-3-like protein; Belongs to the peptidase C14A family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.673
CASP3	GPX4	ENSECAP00000019797	ENSECAP00000023974	Caspase-3-like protein; Belongs to the peptidase C14A family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.596
CASP3	GPX5	ENSECAP00000019797	ENSECAP00000007169	Caspase-3-like protein; Belongs to the peptidase C14A family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.598
CASP3	GPX6	ENSECAP00000019797	ENSECAP00000005820	Caspase-3-like protein; Belongs to the peptidase C14A family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.599
CASP3	GPX7	ENSECAP00000019797	ENSECAP00000018433	Caspase-3-like protein; Belongs to the peptidase C14A family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.691
CASP3	GPX8	ENSECAP00000019797	ENSECAP00000020718	Caspase-3-like protein; Belongs to the peptidase C14A family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.692
CASP3	IL6	ENSECAP00000019797	ENSECAP00000014219	Caspase-3-like protein; Belongs to the peptidase C14A family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.871
ENSECAP00000042890	CASP3	ENSECAP00000042890	ENSECAP00000019797	Uncharacterized protein.	Caspase-3-like protein; Belongs to the peptidase C14A family.	0.678
ENSECAP00000042890	F6W654_HORSE	ENSECAP00000042890	ENSECAP00000001420	Uncharacterized protein.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.597
ENSECAP00000042890	GPX4	ENSECAP00000042890	ENSECAP00000023974	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.780
ENSECAP00000042890	GPX7	ENSECAP00000042890	ENSECAP00000018433	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.604
ENSECAP00000042890	GPX8	ENSECAP00000042890	ENSECAP00000020718	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.460
ENSECAP00000042890	IL6	ENSECAP00000042890	ENSECAP00000014219	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.672
F6W654_HORSE	ENSECAP00000042890	ENSECAP00000001420	ENSECAP00000042890	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	Uncharacterized protein.	0.597