STRINGSTRING
CD19 CD19 GAPDH GAPDH RELB RELB CSF2RB CSF2RB IL22 IL22 S100A10 S100A10 TLR2 TLR2 IRF1 IRF1 EPX EPX PTGS2 PTGS2 IL5 IL5 IL2 IL2 NFKB1 NFKB1 TGFBR2 TGFBR2 VCL VCL MMP9 MMP9 TLR4 TLR4 CD4 CD4 STAT6 STAT6 ID2 ID2 S100A6 S100A6 IRF2 IRF2 CD9 CD9 CXCR4 CXCR4 MYD88 MYD88 TNF TNF CCR1 CCR1 CCR3 CCR3 LOC102149380 LOC102149380 IRF7 IRF7 CCL3 CCL3 IL33 IL33 IL1RN IL1RN IL1B IL1B IRF9 IRF9 CD34 CD34 LOC111768185 LOC111768185 IFNG IFNG CD3E CD3E STAT1 STAT1 CD80 CD80 LOC111771935 LOC111771935 LTF LTF NFKB2 NFKB2 STAT5B STAT5B FOXP3 FOXP3 STAT3 STAT3 IRF5 IRF5 IL17A IL17A IL5RA IL5RA CLEC12A CLEC12A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD19CD19 molecule. (559 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
RELBRELB proto-oncogene, NF-kB subunit. (709 aa)
CSF2RBUncharacterized protein. (901 aa)
IL22Interleukin-22-like protein. (189 aa)
S100A10S100 calcium binding protein A10; Belongs to the S-100 family. (97 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
IRF1Interferon regulatory factor 1. (423 aa)
EPXEosinophil peroxidase. (715 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (666 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa)
NFKB1Nuclear factor kappa B subunit 1. (1049 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (687 aa)
VCLVinculin. (1284 aa)
MMP9Matrix metallopeptidase 9. (714 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
CD4CD4 molecule. (460 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
S100A6Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). (92 aa)
IRF2Interferon regulatory factor 2. (425 aa)
CD9Tetraspanin. (226 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (377 aa)
LOC102149380SERPIN domain-containing protein; Belongs to the serpin family. (385 aa)
IRF7Interferon regulatory factor 7. (536 aa)
CCL3SCY domain-containing protein. (226 aa)
IL33Interleukin 33. (235 aa)
IL1RNInterleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity; Belongs to the IL-1 family. (177 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
IRF9Interferon regulatory factor 9. (394 aa)
CD34CD34 molecule. (379 aa)
LOC111768185Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
CD3ECD3e molecule. (246 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
CD80CD80 molecule. (305 aa)
LOC111771935Toll-like receptor 4. (843 aa)
LTFLactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (715 aa)
NFKB2Nuclear factor kappa B subunit 2. (1024 aa)
STAT5BSignal transducer and activator of transcription. (825 aa)
FOXP3Forkhead box P3. (452 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IRF5Interferon regulatory factor 5. (683 aa)
IL17AUncharacterized protein. (155 aa)
IL5RAInterleukin 5 receptor subunit alpha. (480 aa)
CLEC12AC-type lectin domain family 12 member A. (270 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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