STRINGSTRING
TNF TNF ISG15 ISG15 SOCS3 SOCS3 IFI35 IFI35 TLR6 TLR6 MYD88 MYD88 IFNB1 IFNB1 CCL20 CCL20 IL10RB IL10RB IL4 IL4 OAS3 OAS3 TLR8 TLR8 IL10 IL10 IL13 IL13 TLR4 TLR4 IRAK2 IRAK2 CXCL10 CXCL10 OAS1 OAS1 RELA RELA OASL OASL OAS2 OAS2 IL2 IL2 ACTB ACTB IL6 IL6 MX1 MX1 PTGS2 PTGS2 IRF1 IRF1 TLR2 TLR2 CXCL16 CXCL16 IRF3 IRF3 EBI3 EBI3 JAK1 JAK1 GBP5 GBP5 IL7 IL7 TYK2 TYK2 RELB RELB DDX58 DDX58 STAT2 STAT2 IL1A IL1A CCL2 CCL2 CASP1 CASP1 CCL5 CCL5 SOCS1 SOCS1 IRAK3 IRAK3 IL9 IL9 IFIT3 IFIT3 TLR7 TLR7 IL15 IL15 IDO1 IDO1 TLR1 TLR1 CCL24 CCL24 IFNG IFNG TLR3 TLR3 STAT1 STAT1 RIPK2 RIPK2 LOC111771935 LOC111771935 PIK3AP1 PIK3AP1 IFI6 IFI6 STAT3 STAT3 TLR5 TLR5 IL17A IL17A CXCL1 CXCL1 TNIP2 TNIP2 CCL4 CCL4 IRF7 IRF7 CCL3 CCL3 IL1B IL1B IFNGR2 IFNGR2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
ISG15ISG15 ubiquitin like modifier. (164 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
IFI35Interferon induced protein 35. (280 aa)
TLR6Toll-like receptor. (859 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
IFNB1Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
CCL20C-C motif chemokine. (96 aa)
IL10RBInterleukin 10 receptor subunit beta. (386 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1257 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1038 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
IL13Interleukin-13. (133 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (621 aa)
CXCL10C-X-C motif chemokine. (104 aa)
OAS12'-5'-oligoadenylate synthetase 1. (398 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
OASLUncharacterized protein. (514 aa)
OAS22'-5'-oligoadenylate synthetase 2. (712 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
MX1Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity. (790 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (666 aa)
IRF1Interferon regulatory factor 1. (423 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
CXCL16C-X-C motif chemokine ligand 16. (247 aa)
IRF3Interferon regulatory factor 3. (426 aa)
EBI3Epstein-Barr virus induced 3. (227 aa)
JAK1Tyrosine-protein kinase. (1141 aa)
GBP5GB1/RHD3-type G domain-containing protein. (594 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (176 aa)
TYK2Tyrosine-protein kinase. (1262 aa)
RELBRELB proto-oncogene, NF-kB subunit. (709 aa)
DDX58DExD/H-box helicase 58. (1021 aa)
STAT2Signal transducer and activator of transcription. (847 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
CASP1Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (405 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
SOCS1Suppressor of cytokine signaling 1. (222 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (614 aa)
IL9Interleukin 9. (147 aa)
IFIT3Interferon induced protein with tetratricopeptide repeats 3. (488 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1054 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (432 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (434 aa)
TLR1Toll-like receptor. (756 aa)
CCL24C-C motif chemokine ligand 24. (109 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
LOC111771935Toll-like receptor 4. (843 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (819 aa)
IFI6Interferon alpha inducible protein 6. (132 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (867 aa)
IL17AUncharacterized protein. (155 aa)
CXCL1C-X-C motif chemokine. (113 aa)
TNIP2TNFAIP3 interacting protein 2. (592 aa)
CCL4SCY domain-containing protein. (97 aa)
IRF7Interferon regulatory factor 7. (536 aa)
CCL3SCY domain-containing protein. (226 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
IFNGR2Interferon gamma receptor 2. (461 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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