STRINGSTRING
WTIP WTIP LOC111768663 LOC111768663 UBA2 UBA2 CD163 CD163 F7B565_HORSE F7B565_HORSE MCL1 MCL1 LOC100066329 LOC100066329 LOC100068026 LOC100068026 F6WNE2_HORSE F6WNE2_HORSE PTEN PTEN IL6 IL6 IL2 IL2 LOX LOX PKLR PKLR MMP9 MMP9 CTLA4 CTLA4 IFNB1 IFNB1 IL4 IL4 LOC100146977 LOC100146977 IL10 IL10 CD4 CD4 IL13 IL13 JAK2 JAK2 TLR4 TLR4 EGF EGF SRC SRC PCNA PCNA RPSA RPSA CXCL12 CXCL12 IL1B IL1B PADI3 PADI3 LOC111767413 LOC111767413 LOC100050711 LOC100050711 LOC100055651 LOC100055651 TGFB2 TGFB2 LOC100066444 LOC100066444 MTOR MTOR LOC100068041 LOC100068041 LOC100049805 LOC100049805 COMT COMT FIP1L1 FIP1L1 PDCD4 PDCD4 ENSECAP00000043754 ENSECAP00000043754 PDGFRA PDGFRA TOM1 TOM1 PKM PKM CD86 CD86 ICAM1 ICAM1 BCL2 BCL2 STAT3 STAT3 EGFR EGFR FOXP3 FOXP3 LOC100066501 LOC100066501 LOC111771935 LOC111771935 CD80 CD80 TP53 TP53 STAT1 STAT1 NF2 NF2 CD44 CD44 IFNG IFNG SIRT1 SIRT1 CXCL10 CXCL10 LOC100067994 LOC100067994 CCND1 CCND1 UGT1A1 UGT1A1 GPX4 GPX4 TFRC TFRC MAP1A MAP1A ESR1 ESR1 CASP3 CASP3 SQSTM1 SQSTM1 LOC100050506 LOC100050506 KRAS KRAS TOLLIP TOLLIP JAK1 JAK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WTIPWT1 interacting protein. (428 aa)
LOC111768663Peptidase S1 domain-containing protein. (255 aa)
UBA2SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (650 aa)
CD163CD163 molecule. (1108 aa)
F7B565_HORSEUDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (485 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
LOC100066329UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
LOC100068026UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
F6WNE2_HORSEUDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
PTENPhosphatase and tensin homolog. (576 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa)
LOXLysyl oxidase. (481 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (543 aa)
MMP9Matrix metallopeptidase 9. (714 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
IFNB1Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
LOC100146977UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
CD4CD4 molecule. (460 aa)
IL13Interleukin-13. (133 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
SRCTyrosine-protein kinase. (551 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RPSA40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (295 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
PADI3Peptidyl arginine deiminase 4. (1184 aa)
LOC111767413Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (252 aa)
LOC100050711Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (269 aa)
LOC100055651Peptidase S1 domain-containing protein. (244 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC100066444UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
LOC100068041UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (329 aa)
LOC100049805Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (302 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. (393 aa)
FIP1L1Factor interacting with PAPOLA and CPSF1. (603 aa)
PDCD4Programmed cell death 4. (479 aa)
ENSECAP00000043754UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (523 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
TOM1Target of myb1 membrane trafficking protein; Belongs to the TOM1 family. (510 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (720 aa)
CD86CD86 molecule. (335 aa)
ICAM1Intercellular adhesion molecule 1. (628 aa)
BCL2BCL2 apoptosis regulator. (285 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
FOXP3Forkhead box P3. (452 aa)
LOC100066501UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
LOC111771935Toll-like receptor 4. (843 aa)
CD80CD80 molecule. (305 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
NF2Neurofibromin 2. (637 aa)
CD44CD44 antigen. (700 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
SIRT1Sirtuin 1. (737 aa)
CXCL10C-X-C motif chemokine. (104 aa)
LOC100067994UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
UGT1A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (199 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (767 aa)
MAP1AMicrotubule associated protein 1A. (3073 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (608 aa)
CASP3Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa)
SQSTM1Sequestosome 1. (440 aa)
LOC10005050640S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (284 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
TOLLIPToll interacting protein. (274 aa)
JAK1Tyrosine-protein kinase. (1141 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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