STRINGSTRING
CEBPA CEBPA NCAM1 NCAM1 AADAC AADAC PLIN1 PLIN1 PLAC9 PLAC9 ASTL ASTL MYOC MYOC MME MME GPC3 GPC3 THY1 THY1 WNT5A WNT5A IL4 IL4 G0S2 G0S2 TAC1 TAC1 ADIPOQ ADIPOQ CCR2 CCR2 NKD2 NKD2 PTGDS PTGDS PLIN2 PLIN2 COL1A1 COL1A1 SCN7A SCN7A TLL2 TLL2 SFRP2 SFRP2 LUM LUM AXIN2 AXIN2 WNT4 WNT4 FBN1 FBN1 RSPO3 RSPO3 PCOLCE2 PCOLCE2 APOD APOD SOX9 SOX9 BMP1 BMP1 CASP3 CASP3 AADAC-2 AADAC-2 INS INS CRISPLD2 CRISPLD2 WNT2 WNT2 PI16 PI16 CD34 CD34 ACTA2 ACTA2 VCAM1 VCAM1 CD82 CD82 TNXB TNXB ATP1A2 ATP1A2 RUNX2 RUNX2 MFAP5 MFAP5 CD36 CD36 FABP4 FABP4 WNT10B WNT10B LEP LEP DPP4 DPP4 SMOC2 SMOC2 ICAM1 ICAM1 CD55 CD55 ALB ALB TLL1 TLL1 CXCL14 CXCL14 PDGFRA PDGFRA PLIN5 PLIN5 VWA1 VWA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CEBPACCAAT enhancer binding protein alpha. (358 aa)
NCAM1Neural cell adhesion molecule 1. (1129 aa)
AADACArylacetamide deacetylase. (399 aa)
PLIN1Perilipin; Belongs to the perilipin family. (522 aa)
PLAC9Placenta associated 9. (99 aa)
ASTLMetalloendopeptidase. (429 aa)
MYOCMyocilin. (490 aa)
MMEMembrane metalloendopeptidase. (750 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (611 aa)
THY1Thy-1 cell surface antigen. (161 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
G0S2G0/G1 switch 2. (98 aa)
TAC1Substance P. (130 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (301 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (380 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (553 aa)
PTGDSProstaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] (200 aa)
PLIN2Perilipin; Belongs to the perilipin family. (436 aa)
COL1A1Collagen type I alpha 1 chain. (1521 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1677 aa)
TLL2Metalloendopeptidase. (1020 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
LUMLumican. (341 aa)
AXIN2Axin 2. (843 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FBN1Fibrillin 1. (3030 aa)
RSPO3R-spondin 3. (288 aa)
PCOLCE2Procollagen C-endopeptidase enhancer 2. (414 aa)
APODApolipoprotein D. (213 aa)
SOX9SRY-box 9. (509 aa)
BMP1Metalloendopeptidase. (1083 aa)
CASP3Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa)
AADAC-2Arylacetamide deacetylase. (278 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CRISPLD2Cysteine rich secretory protein LCCL domain containing 2. (570 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (454 aa)
CD34CD34 molecule. (379 aa)
ACTA2Actin alpha 2, smooth muscle. (406 aa)
VCAM1Vascular cell adhesion molecule 1. (786 aa)
CD82Tetraspanin. (352 aa)
TNXBTenascin XB. (673 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1045 aa)
RUNX2Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activati [...] (634 aa)
MFAP5Uncharacterized protein. (275 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (183 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (869 aa)
SMOC2SPARC related modular calcium binding 2. (646 aa)
ICAM1Intercellular adhesion molecule 1. (628 aa)
CD55Uncharacterized protein. (411 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (620 aa)
TLL1Metalloendopeptidase. (1041 aa)
CXCL14C-X-C motif chemokine ligand 14. (125 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PLIN5Perilipin; Belongs to the perilipin family. (457 aa)
VWA1Von Willebrand factor A domain containing 1. (499 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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