(25 nodes) (2022) NK cell-derived exosomes enhance the anti-tumor effects against ovarian cancer by delivering cisplatin and reactivating NK cell functions. network (Equus caballus)

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Known Interactions

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Predicted Interactions

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Your Input:
	CXCL11	C-X-C motif chemokine. (100 aa)
	LOC111768663	Peptidase S1 domain-containing protein. (255 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
	CANX	Calnexin. (575 aa)
	TSG101	Tumor susceptibility 101. (390 aa)
	CD81	Tetraspanin. (393 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
	ITGAL	Integrin subunit alpha L; Belongs to the integrin alpha chain family. (1168 aa)
	CD48	CD48 molecule. (243 aa)
	CXCL10	C-X-C motif chemokine. (104 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
	CASP3	Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa)
	CD244	CD244 molecule. (374 aa)
	CD69	CD69 molecule. (199 aa)
	GZMA	Granzyme A; Belongs to the peptidase S1 family. (321 aa)
	CXCR3	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	CX3CL1	SCY domain-containing protein. (561 aa)
	IL17A	Uncharacterized protein. (155 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (347 aa)
	LOC100049805	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (302 aa)
	FCAR	Natural cytotoxicity triggering receptor 1. (539 aa)
	LOC100055651	Peptidase S1 domain-containing protein. (244 aa)
	LOC100050711	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (269 aa)
	LOC111767413	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (252 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CANX	ENSECAP00000013637	ENSECAP00000003374	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Calnexin.	0.577
ACTB	CASP3	ENSECAP00000013637	ENSECAP00000019797	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Caspase-3-like protein; Belongs to the peptidase C14A family.	0.995
ACTB	CASP7	ENSECAP00000013637	ENSECAP00000045690	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Caspase 7; Belongs to the peptidase C14A family.	0.558
ACTB	CD81	ENSECAP00000013637	ENSECAP00000005003	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Tetraspanin.	0.465
ACTB	CXCL10	ENSECAP00000013637	ENSECAP00000011110	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	C-X-C motif chemokine.	0.455
ACTB	IL10	ENSECAP00000013637	ENSECAP00000007097	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.707
ACTB	IL17A	ENSECAP00000013637	ENSECAP00000039926	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Uncharacterized protein.	0.516
ACTB	IL2	ENSECAP00000013637	ENSECAP00000013353	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.527
ACTB	TNF	ENSECAP00000013637	ENSECAP00000001460	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.801
ACTB	TSG101	ENSECAP00000013637	ENSECAP00000004256	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Tumor susceptibility 101.	0.494
CANX	ACTB	ENSECAP00000003374	ENSECAP00000013637	Calnexin.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.577
CANX	CASP3	ENSECAP00000003374	ENSECAP00000019797	Calnexin.	Caspase-3-like protein; Belongs to the peptidase C14A family.	0.549
CANX	CD81	ENSECAP00000003374	ENSECAP00000005003	Calnexin.	Tetraspanin.	0.803
CANX	TSG101	ENSECAP00000003374	ENSECAP00000004256	Calnexin.	Tumor susceptibility 101.	0.857
CASP3	ACTB	ENSECAP00000019797	ENSECAP00000013637	Caspase-3-like protein; Belongs to the peptidase C14A family.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.995
CASP3	CANX	ENSECAP00000019797	ENSECAP00000003374	Caspase-3-like protein; Belongs to the peptidase C14A family.	Calnexin.	0.549
CASP3	CASP7	ENSECAP00000019797	ENSECAP00000045690	Caspase-3-like protein; Belongs to the peptidase C14A family.	Caspase 7; Belongs to the peptidase C14A family.	0.710
CASP3	CXCL10	ENSECAP00000019797	ENSECAP00000011110	Caspase-3-like protein; Belongs to the peptidase C14A family.	C-X-C motif chemokine.	0.485
CASP3	IL10	ENSECAP00000019797	ENSECAP00000007097	Caspase-3-like protein; Belongs to the peptidase C14A family.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.702
CASP3	IL17A	ENSECAP00000019797	ENSECAP00000039926	Caspase-3-like protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.475