(16 nodes) (2023) The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization. network (Equus caballus)

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Your Input:
	AREG	Amphiregulin. (247 aa)
	RPL7	Uncharacterized protein. (261 aa)
	LOC100050112	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (257 aa)
	ADAM17	ADAM metallopeptidase domain 17. (891 aa)
	HBEGF	Heparin binding EGF like growth factor. (390 aa)
	HMGB3	High mobility group box 3. (310 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1308 aa)
	EREG	Epiregulin. (170 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
	HMGB1	High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
	PGR	Progesterone receptor. (934 aa)
	LOC100049983	Uncharacterized protein; Belongs to the peptidase S1 family. (246 aa)
	IGFBP1	Insulin like growth factor binding protein 1. (268 aa)
	LOC100055297	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM17	AREG	ENSECAP00000033466	ENSECAP00000019991	ADAM metallopeptidase domain 17.	Amphiregulin.	0.720
ADAM17	EGF	ENSECAP00000033466	ENSECAP00000009190	ADAM metallopeptidase domain 17.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.517
ADAM17	ERBB4	ENSECAP00000033466	ENSECAP00000020577	ADAM metallopeptidase domain 17.	Receptor protein-tyrosine kinase.	0.512
ADAM17	EREG	ENSECAP00000033466	ENSECAP00000005626	ADAM metallopeptidase domain 17.	Epiregulin.	0.584
ADAM17	HBEGF	ENSECAP00000033466	ENSECAP00000024751	ADAM metallopeptidase domain 17.	Heparin binding EGF like growth factor.	0.681
ADAM17	TNF	ENSECAP00000033466	ENSECAP00000001460	ADAM metallopeptidase domain 17.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.873
AREG	ADAM17	ENSECAP00000019991	ENSECAP00000033466	Amphiregulin.	ADAM metallopeptidase domain 17.	0.720
AREG	EGF	ENSECAP00000019991	ENSECAP00000009190	Amphiregulin.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.882
AREG	ERBB4	ENSECAP00000019991	ENSECAP00000020577	Amphiregulin.	Receptor protein-tyrosine kinase.	0.928
AREG	EREG	ENSECAP00000019991	ENSECAP00000005626	Amphiregulin.	Epiregulin.	0.987
AREG	HBEGF	ENSECAP00000019991	ENSECAP00000024751	Amphiregulin.	Heparin binding EGF like growth factor.	0.679
AREG	PGR	ENSECAP00000019991	ENSECAP00000009675	Amphiregulin.	Progesterone receptor.	0.665
EGF	ADAM17	ENSECAP00000009190	ENSECAP00000033466	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	ADAM metallopeptidase domain 17.	0.517
EGF	AREG	ENSECAP00000009190	ENSECAP00000019991	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Amphiregulin.	0.882
EGF	ERBB4	ENSECAP00000009190	ENSECAP00000020577	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Receptor protein-tyrosine kinase.	0.990
EGF	EREG	ENSECAP00000009190	ENSECAP00000005626	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Epiregulin.	0.697
EGF	HBEGF	ENSECAP00000009190	ENSECAP00000024751	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Heparin binding EGF like growth factor.	0.882
EGF	PGR	ENSECAP00000009190	ENSECAP00000009675	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Progesterone receptor.	0.808
EGF	STAT3	ENSECAP00000009190	ENSECAP00000036035	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Signal transducer and activator of transcription.	0.775
EGF	TNF	ENSECAP00000009190	ENSECAP00000001460	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.710