STRINGSTRING
IRF1 IRF1 TNFRSF4 TNFRSF4 STAT2 STAT2 PXDNL PXDNL CXCR3 CXCR3 CCL2 CCL2 LOC100068926 LOC100068926 IDO1 IDO1 IFNG IFNG STAT1 STAT1 STAT3 STAT3 PXDN PXDN ALB ALB XCL1 XCL1 CCL4 CCL4 CCL3 CCL3 LOC100049805 LOC100049805 LOC100055651 LOC100055651 LOC100050711 LOC100050711 LOC111767413 LOC111767413 LOC111768663 LOC111768663 TNF TNF CD4 CD4 IFNGR1 IFNGR1 JAK2 JAK2 CXCL11 CXCL11 CXCL10 CXCL10 IL2 IL2 TNFRSF9 TNFRSF9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRF1Interferon regulatory factor 1. (423 aa)
TNFRSF4TNF receptor superfamily member 4. (320 aa)
STAT2Signal transducer and activator of transcription. (847 aa)
PXDNLPeroxidasin like. (1243 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (369 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
LOC100068926Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. (186 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (434 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PXDNPeroxidasin. (1596 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (620 aa)
XCL1SCY domain-containing protein. (206 aa)
CCL4SCY domain-containing protein. (97 aa)
CCL3SCY domain-containing protein. (226 aa)
LOC100049805Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (302 aa)
LOC100055651Peptidase S1 domain-containing protein. (244 aa)
LOC100050711Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (269 aa)
LOC111767413Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (252 aa)
LOC111768663Peptidase S1 domain-containing protein. (255 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
CD4CD4 molecule. (460 aa)
IFNGR1Interferon gamma receptor 1. (472 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
CXCL11C-X-C motif chemokine. (100 aa)
CXCL10C-X-C motif chemokine. (104 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa)
TNFRSF9TNF receptor superfamily member 9. (256 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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