(23 nodes) (2023) T Cells in Tick-Borne Flavivirus Encephalitis: A Review of Current Paradigms in Protection and Disease Pathology. network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IRF3	Interferon regulatory factor 3. (426 aa)
	EOMES	Eomesodermin. (702 aa)
	CD69	CD69 molecule. (199 aa)
	CXCR3	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	CXCL10	C-X-C motif chemokine. (104 aa)
	CXCL11	C-X-C motif chemokine. (100 aa)
	LOC111767413	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (252 aa)
	LOC100050711	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (269 aa)
	LOC100055651	Peptidase S1 domain-containing protein. (244 aa)
	LOC100049805	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (302 aa)
	CCL3	SCY domain-containing protein. (226 aa)
	CD86	CD86 molecule. (335 aa)
	BCL2	BCL2 apoptosis regulator. (285 aa)
	CD27	CD27 molecule. (257 aa)
	CD4	CD4 molecule. (460 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (451 aa)
	CCR2	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	LOC111768663	Peptidase S1 domain-containing protein. (255 aa)
	IL1A	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
	CCL5	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
	FOXP3	Forkhead box P3. (452 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	CD4	ENSECAP00000037719	ENSECAP00000007248	BCL2 apoptosis regulator.	CD4 molecule.	0.668
BCL2	FOXP3	ENSECAP00000037719	ENSECAP00000035296	BCL2 apoptosis regulator.	Forkhead box P3.	0.593
BCL2	IL6	ENSECAP00000037719	ENSECAP00000014219	BCL2 apoptosis regulator.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.808
CCL3	CCL5	ENSECAP00000047808	ENSECAP00000022430	SCY domain-containing protein.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.710
CCL3	CCR2	ENSECAP00000047808	ENSECAP00000000857	SCY domain-containing protein.	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.848
CCL3	CCR6	ENSECAP00000047808	ENSECAP00000035393	SCY domain-containing protein.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.713
CCL3	CCR7	ENSECAP00000047808	ENSECAP00000003375	SCY domain-containing protein.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.750
CCL3	CD4	ENSECAP00000047808	ENSECAP00000007248	SCY domain-containing protein.	CD4 molecule.	0.781
CCL3	CD86	ENSECAP00000047808	ENSECAP00000040346	SCY domain-containing protein.	CD86 molecule.	0.625
CCL3	CXCL10	ENSECAP00000047808	ENSECAP00000011110	SCY domain-containing protein.	C-X-C motif chemokine.	0.951
CCL3	CXCL11	ENSECAP00000047808	ENSECAP00000010001	SCY domain-containing protein.	C-X-C motif chemokine.	0.802
CCL3	CXCR3	ENSECAP00000047808	ENSECAP00000020988	SCY domain-containing protein.	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.685
CCL3	FOXP3	ENSECAP00000047808	ENSECAP00000035296	SCY domain-containing protein.	Forkhead box P3.	0.517
CCL3	IL1A	ENSECAP00000047808	ENSECAP00000021137	SCY domain-containing protein.	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).	0.917
CCL3	IL6	ENSECAP00000047808	ENSECAP00000014219	SCY domain-containing protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.929
CCL3	IRF3	ENSECAP00000047808	ENSECAP00000015946	SCY domain-containing protein.	Interferon regulatory factor 3.	0.472
CCL3	LOC100049805	ENSECAP00000047808	ENSECAP00000047892	SCY domain-containing protein.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.400
CCL3	LOC100050711	ENSECAP00000047808	ENSECAP00000052841	SCY domain-containing protein.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.415
CCL3	LOC100055651	ENSECAP00000047808	ENSECAP00000051796	SCY domain-containing protein.	Peptidase S1 domain-containing protein.	0.400
CCL3	LOC111767413	ENSECAP00000047808	ENSECAP00000053464	SCY domain-containing protein.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.415