STRINGSTRING
PRL PRL NAB2 NAB2 ASPN ASPN NAB1 NAB1 EGR2 EGR2 GLI1 GLI1 FOXH1 FOXH1 FGF10 FGF10 PITX1 PITX1 LOX LOX TGFBR2 TGFBR2 SIX2 SIX2 TLR2 TLR2 TWSG1 TWSG1 LUM LUM TNMD TNMD MYF5 MYF5 THBS4 THBS4 PCOLCE PCOLCE FGF6 FGF6 FHL2 FHL2 INS INS GSK3B GSK3B COL1A2 COL1A2 COL6A1 COL6A1 TCF7L2 TCF7L2 SOX6 SOX6 NR4A1 NR4A1 KERA KERA RUNX2 RUNX2 HOXC10 HOXC10 FMOD FMOD TGFB3 TGFB3 NID2 NID2 DUSP6 DUSP6 ACAN ACAN FGF4 FGF4 SMAD3 SMAD3 BMP7 BMP7 EYA1 EYA1 MKX MKX COL2A1 COL2A1 SOX5 SOX5 COL5A1 COL5A1 TGFB2 TGFB2 COL11A1 COL11A1 COL1A1 COL1A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (234 aa)
NAB2NGFI-A binding protein 2. (716 aa)
ASPNAsporin. (370 aa)
NAB1NGFI-A binding protein 1. (485 aa)
EGR2Early growth response 2. (486 aa)
GLI1GLI family zinc finger 1. (1106 aa)
FOXH1Forkhead box H1. (360 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PITX1Homeobox protein. (314 aa)
LOXLysyl oxidase. (481 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (687 aa)
SIX2SIX homeobox 2. (296 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
LUMLumican. (341 aa)
TNMDTenomodulin. (317 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
THBS4Thrombospondin 4. (961 aa)
PCOLCEProcollagen C-endopeptidase enhancer. (459 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FHL2Four and a half LIM domains 2. (279 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
COL1A2Collagen type I alpha 2 chain. (1364 aa)
COL6A1Collagen type VI alpha 1 chain. (1027 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
SOX6SRY-box 6. (870 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (852 aa)
KERAKeratocan. (389 aa)
RUNX2Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activati [...] (634 aa)
HOXC10Homeobox C10. (342 aa)
FMODFibromodulin. (392 aa)
TGFB3Transforming growth factor beta 3. (490 aa)
NID2Nidogen 2. (1359 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (354 aa)
ACANAggrecan. (2703 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
BMP7Bone morphogenetic protein 7. (437 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
MKXMohawk homeobox. (352 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
SOX5SRY-box 5. (827 aa)
COL5A1Collagen type V alpha 1 chain. (1813 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
COL11A1Collagen type XI alpha 1 chain. (1818 aa)
COL1A1Collagen type I alpha 1 chain. (1521 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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