(14 nodes) (2023) Exploration of Mediators Associated with Myocardial Remodelling in Feline Hypertrophic Cardiomyopathy. network (Equus caballus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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Your Input:
	ACTA2	Actin alpha 2, smooth muscle. (406 aa)
	TGM2	Transglutaminase 2. (687 aa)
	LOX	Lysyl oxidase. (481 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
	LUM	Lumican. (341 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	PXDNL	Peroxidasin like. (1243 aa)
	LOXL1	Lysyl oxidase like 1. (578 aa)
	COL3A1	Collagen type III alpha 1 chain. (1466 aa)
	COL1A2	Collagen type I alpha 2 chain. (1364 aa)
	LOXL2	Lysyl oxidase like 2. (1047 aa)
	PXDN	Peroxidasin. (1596 aa)
	MYH6	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2081 aa)
	COL1A1	Collagen type I alpha 1 chain. (1521 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA2	COL1A1	ENSECAP00000023220	ENSECAP00000054911	Actin alpha 2, smooth muscle.	Collagen type I alpha 1 chain.	0.707
ACTA2	COL1A2	ENSECAP00000023220	ENSECAP00000022567	Actin alpha 2, smooth muscle.	Collagen type I alpha 2 chain.	0.476
ACTA2	COL3A1	ENSECAP00000023220	ENSECAP00000022362	Actin alpha 2, smooth muscle.	Collagen type III alpha 1 chain.	0.561
ACTA2	GAPDH	ENSECAP00000023220	ENSECAP00000019665	Actin alpha 2, smooth muscle.	Glyceraldehyde-3-phosphate dehydrogenase.	0.485
ACTA2	MYH6	ENSECAP00000023220	ENSECAP00000049644	Actin alpha 2, smooth muscle.	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.888
ACTB	COL1A1	ENSECAP00000013637	ENSECAP00000054911	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Collagen type I alpha 1 chain.	0.565
ACTB	GAPDH	ENSECAP00000013637	ENSECAP00000019665	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Glyceraldehyde-3-phosphate dehydrogenase.	0.967
ACTB	LOX	ENSECAP00000013637	ENSECAP00000012463	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Lysyl oxidase.	0.487
ACTB	MYH6	ENSECAP00000013637	ENSECAP00000049644	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.540
ACTB	PXDN	ENSECAP00000013637	ENSECAP00000040420	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Peroxidasin.	0.956
ACTB	PXDNL	ENSECAP00000013637	ENSECAP00000020314	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Peroxidasin like.	0.956
COL1A1	ACTA2	ENSECAP00000054911	ENSECAP00000023220	Collagen type I alpha 1 chain.	Actin alpha 2, smooth muscle.	0.707
COL1A1	ACTB	ENSECAP00000054911	ENSECAP00000013637	Collagen type I alpha 1 chain.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.565
COL1A1	COL1A2	ENSECAP00000054911	ENSECAP00000022567	Collagen type I alpha 1 chain.	Collagen type I alpha 2 chain.	0.999
COL1A1	COL3A1	ENSECAP00000054911	ENSECAP00000022362	Collagen type I alpha 1 chain.	Collagen type III alpha 1 chain.	0.992
COL1A1	GAPDH	ENSECAP00000054911	ENSECAP00000019665	Collagen type I alpha 1 chain.	Glyceraldehyde-3-phosphate dehydrogenase.	0.782
COL1A1	LOX	ENSECAP00000054911	ENSECAP00000012463	Collagen type I alpha 1 chain.	Lysyl oxidase.	0.720
COL1A1	LOXL1	ENSECAP00000054911	ENSECAP00000020935	Collagen type I alpha 1 chain.	Lysyl oxidase like 1.	0.531
COL1A1	LOXL2	ENSECAP00000054911	ENSECAP00000022653	Collagen type I alpha 1 chain.	Lysyl oxidase like 2.	0.537
COL1A1	LUM	ENSECAP00000054911	ENSECAP00000015833	Collagen type I alpha 1 chain.	Lumican.	0.892