STRINGSTRING
CALML4 CALML4 FOLR2 FOLR2 HYAL3 HYAL3 HYAL2 HYAL2 MPL MPL ACTB ACTB FOS FOS LOC111770212 LOC111770212 MIF MIF ATF3 ATF3 CALM1 CALM1 LYVE1 LYVE1 APOE APOE CLEC4E CLEC4E CXCR2 CXCR2 CALML3 CALML3 SPAM1 SPAM1 CX3CR1 CX3CR1 DDIT4 DDIT4 CXCR4 CXCR4 CD68 CD68 TNF TNF CCR2 CCR2 CD3E CD3E CD36 CD36 CD44 CD44 LGALS3 LGALS3 HYAL4 HYAL4 CEBPB CEBPB PDGFRB PDGFRB INS INS CD19 CD19 MERTK MERTK JUN JUN CCL2 CCL2 CALML5 CALML5 LOC106783049 LOC106783049 CXCR3 CXCR3 PXDNL PXDNL GAPDH GAPDH CXCL12 CXCL12 IRF8 IRF8 MYH11 MYH11 B2M B2M HOXB8 HOXB8 PXDN PXDN FKBP5 FKBP5 CD80 CD80 FABP4 FABP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALML4Calmodulin like 4. (197 aa)
FOLR2Folate_rec domain-containing protein. (253 aa)
HYAL3Hyaluronidase. (415 aa)
HYAL2Hyaluronidase. (710 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (631 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
LOC111770212C-C motif chemokine. (100 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
ATF3Activating transcription factor 3. (251 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (336 aa)
LYVE1Lymphatic vessel endothelial hyaluronan receptor 1. (324 aa)
APOEApolipoprotein E. (310 aa)
CLEC4EC-type lectin domain family 4 member E. (217 aa)
CXCR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (354 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
SPAM1Hyaluronidase. (569 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (386 aa)
DDIT4DNA damage inducible transcript 4. (231 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CD68Macrosialin-like protein. (322 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (380 aa)
CD3ECD3e molecule. (246 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
CD44CD44 antigen. (700 aa)
LGALS3Galectin. (376 aa)
HYAL4Hyaluronidase. (481 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CD19CD19 molecule. (559 aa)
MERTKMER proto-oncogene, tyrosine kinase. (993 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
CALML5Calmodulin like 5. (149 aa)
LOC106783049Hyaluronidase. (496 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (369 aa)
PXDNLPeroxidasin like. (1243 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
IRF8Interferon regulatory factor 8. (492 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (125 aa)
HOXB8Homeobox B8. (242 aa)
PXDNPeroxidasin. (1596 aa)
FKBP5Peptidylprolyl isomerase. (455 aa)
CD80CD80 molecule. (305 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (183 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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