26 items (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLD1	Phospholipase. (1189 aa)
	LOC102148861	Profilin; Belongs to the profilin family. (153 aa)
	INPP4B	Inositol polyphosphate-4-phosphatase type II B. (937 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
	FLNA	Filamin A. (2647 aa)
	SRC	Tyrosine-protein kinase. (551 aa)
	PLD2	Phospholipase. (933 aa)
	PTEN	Phosphatase and tensin homolog. (576 aa)
	TLN1	Talin 1. (2558 aa)
	PFN1	Profilin; Belongs to the profilin family. (166 aa)
	TLN2	Talin 2. (2572 aa)
	PXDNL	Peroxidasin like. (1243 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	INPP1	Inositol polyphosphate-1-phosphatase. (400 aa)
	ND2	NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (346 aa)
	CDC42	Cell division control protein 42-like protein. (191 aa)
	PLEK2	Pleckstrin 2. (362 aa)
	PFN2	Profilin; Belongs to the profilin family. (188 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1226 aa)
	PLEK	Pleckstrin. (362 aa)
	EGFR	Receptor protein-tyrosine kinase. (1195 aa)
	RHOA	Transforming protein RhoA-like protein. (193 aa)
	PXDN	Peroxidasin. (1596 aa)
	PIP4K2A	Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (587 aa)
	FLNC	Filamin C. (2917 aa)
	FLNB	Filamin B. (2633 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	EGF	ENSECAP00000025414	ENSECAP00000009190	Cell division control protein 42-like protein.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.748
CDC42	EGFR	ENSECAP00000025414	ENSECAP00000035347	Cell division control protein 42-like protein.	Receptor protein-tyrosine kinase.	0.798
CDC42	FLNA	ENSECAP00000025414	ENSECAP00000009429	Cell division control protein 42-like protein.	Filamin A.	0.849
CDC42	FLNB	ENSECAP00000025414	ENSECAP00000052323	Cell division control protein 42-like protein.	Filamin B.	0.544
CDC42	FLNC	ENSECAP00000025414	ENSECAP00000047435	Cell division control protein 42-like protein.	Filamin C.	0.730
CDC42	INS	ENSECAP00000025414	ENSECAP00000022114	Cell division control protein 42-like protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.540
CDC42	LOC102148861	ENSECAP00000025414	ENSECAP00000002949	Cell division control protein 42-like protein.	Profilin; Belongs to the profilin family.	0.655
CDC42	PFN1	ENSECAP00000025414	ENSECAP00000018633	Cell division control protein 42-like protein.	Profilin; Belongs to the profilin family.	0.672
CDC42	PFN2	ENSECAP00000025414	ENSECAP00000029481	Cell division control protein 42-like protein.	Profilin; Belongs to the profilin family.	0.667
CDC42	PLEK	ENSECAP00000025414	ENSECAP00000035289	Cell division control protein 42-like protein.	Pleckstrin.	0.819
CDC42	PLEK2	ENSECAP00000025414	ENSECAP00000025745	Cell division control protein 42-like protein.	Pleckstrin 2.	0.827
CDC42	PTEN	ENSECAP00000025414	ENSECAP00000014788	Cell division control protein 42-like protein.	Phosphatase and tensin homolog.	0.950
CDC42	PXDN	ENSECAP00000025414	ENSECAP00000040420	Cell division control protein 42-like protein.	Peroxidasin.	0.582
CDC42	PXDNL	ENSECAP00000025414	ENSECAP00000020314	Cell division control protein 42-like protein.	Peroxidasin like.	0.582
CDC42	RHOA	ENSECAP00000025414	ENSECAP00000036784	Cell division control protein 42-like protein.	Transforming protein RhoA-like protein.	0.967
CDC42	SRC	ENSECAP00000025414	ENSECAP00000010024	Cell division control protein 42-like protein.	Tyrosine-protein kinase.	0.987
CDC42	TLN1	ENSECAP00000025414	ENSECAP00000015561	Cell division control protein 42-like protein.	Talin 1.	0.632
CDC42	TLN2	ENSECAP00000025414	ENSECAP00000019323	Cell division control protein 42-like protein.	Talin 2.	0.603
EGF	CDC42	ENSECAP00000009190	ENSECAP00000025414	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Cell division control protein 42-like protein.	0.748
EGF	EGFR	ENSECAP00000009190	ENSECAP00000035347	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Receptor protein-tyrosine kinase.	0.999