(19 nodes) (2023) Red Cabbage Juice-Mediated Gut Microbiota Modulation Improves Intestinal Epithelial Homeostasis and Ameliorates Colitis. network (Equus caballus)

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Known Interactions

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Predicted Interactions

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Your Input:
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
	MUC4	Uncharacterized protein. (1173 aa)
	IL17A	Uncharacterized protein. (155 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	FOXP3	Forkhead box P3. (452 aa)
	CCL1	SCY domain-containing protein. (94 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
	GPX4	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (199 aa)
	IL1A	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
	CLDN1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	F6W654_HORSE	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (216 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
	CD4	CD4 molecule. (460 aa)
	OCLN	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (520 aa)
	IL13	Interleukin-13. (133 aa)
	CXCL11	C-X-C motif chemokine. (100 aa)
	CXCL10	C-X-C motif chemokine. (104 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL1	CD4	ENSECAP00000034342	ENSECAP00000007248	SCY domain-containing protein.	CD4 molecule.	0.416
CCL1	CXCL10	ENSECAP00000034342	ENSECAP00000011110	SCY domain-containing protein.	C-X-C motif chemokine.	0.870
CCL1	CXCL11	ENSECAP00000034342	ENSECAP00000010001	SCY domain-containing protein.	C-X-C motif chemokine.	0.974
CCL1	IFNG	ENSECAP00000034342	ENSECAP00000030547	SCY domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.556
CCL1	IL10	ENSECAP00000034342	ENSECAP00000007097	SCY domain-containing protein.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.574
CCL1	IL13	ENSECAP00000034342	ENSECAP00000007732	SCY domain-containing protein.	Interleukin-13.	0.513
CCL1	IL17A	ENSECAP00000034342	ENSECAP00000039926	SCY domain-containing protein.	Uncharacterized protein.	0.469
CCL1	IL1A	ENSECAP00000034342	ENSECAP00000021137	SCY domain-containing protein.	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).	0.496
CCL1	IL1B	ENSECAP00000034342	ENSECAP00000053627	SCY domain-containing protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells.	0.525
CCL1	IL5	ENSECAP00000034342	ENSECAP00000014377	SCY domain-containing protein.	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.	0.450
CCL1	IL6	ENSECAP00000034342	ENSECAP00000014219	SCY domain-containing protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.563
CD4	CCL1	ENSECAP00000007248	ENSECAP00000034342	CD4 molecule.	SCY domain-containing protein.	0.416
CD4	CXCL10	ENSECAP00000007248	ENSECAP00000011110	CD4 molecule.	C-X-C motif chemokine.	0.804
CD4	CXCL11	ENSECAP00000007248	ENSECAP00000010001	CD4 molecule.	C-X-C motif chemokine.	0.602
CD4	FOXP3	ENSECAP00000007248	ENSECAP00000035296	CD4 molecule.	Forkhead box P3.	0.963
CD4	IFNG	ENSECAP00000007248	ENSECAP00000030547	CD4 molecule.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.971
CD4	IL10	ENSECAP00000007248	ENSECAP00000007097	CD4 molecule.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.969
CD4	IL13	ENSECAP00000007248	ENSECAP00000007732	CD4 molecule.	Interleukin-13.	0.887
CD4	IL17A	ENSECAP00000007248	ENSECAP00000039926	CD4 molecule.	Uncharacterized protein.	0.966
CD4	IL1A	ENSECAP00000007248	ENSECAP00000021137	CD4 molecule.	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).	0.771