(15 nodes) Low-density lipoprotein-receptor YWTD domain network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NID2	Nidogen 2. (1359 aa)
	LRP2	LDL receptor related protein 2. (4673 aa)
	LRP1	LDL receptor related protein 1. (4567 aa)
	LDLR	Low density lipoprotein receptor. (937 aa)
	LRP8	LDL receptor related protein 8. (1011 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
	NID1	Nidogen 1. (1244 aa)
	LRP4	LDL receptor related protein 4. (1905 aa)
	ROS1	Tyrosine-protein kinase receptor. (2342 aa)
	ENSECAP00000023688	Uncharacterized protein. (2180 aa)
	VLDLR	Very low density lipoprotein receptor. (1140 aa)
	SORL1	Sortilin related receptor 1. (2255 aa)
	LRP1B	LDL receptor related protein 1B. (4599 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGF	ENSECAP00000023688	ENSECAP00000009190	ENSECAP00000023688	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Uncharacterized protein.	0.418
EGF	LRP2	ENSECAP00000009190	ENSECAP00000040585	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	LDL receptor related protein 2.	0.418
ENSECAP00000023688	EGF	ENSECAP00000023688	ENSECAP00000009190	Uncharacterized protein.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.418
LRP1	LRP2	ENSECAP00000044262	ENSECAP00000040585	LDL receptor related protein 1.	LDL receptor related protein 2.	0.906
LRP2	EGF	ENSECAP00000040585	ENSECAP00000009190	LDL receptor related protein 2.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.418
LRP2	LRP1	ENSECAP00000040585	ENSECAP00000044262	LDL receptor related protein 2.	LDL receptor related protein 1.	0.906
LRP2	LRP5	ENSECAP00000040585	ENSECAP00000037465	LDL receptor related protein 2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.472
LRP2	LRP6	ENSECAP00000040585	ENSECAP00000005754	LDL receptor related protein 2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.492
LRP2	VLDLR	ENSECAP00000040585	ENSECAP00000028774	LDL receptor related protein 2.	Very low density lipoprotein receptor.	0.428
LRP5	LRP2	ENSECAP00000037465	ENSECAP00000040585	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	LDL receptor related protein 2.	0.472
LRP5	LRP6	ENSECAP00000037465	ENSECAP00000005754	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.988
LRP6	LRP2	ENSECAP00000005754	ENSECAP00000040585	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	LDL receptor related protein 2.	0.492
LRP6	LRP5	ENSECAP00000005754	ENSECAP00000037465	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.988
LRP8	VLDLR	ENSECAP00000054730	ENSECAP00000028774	LDL receptor related protein 8.	Very low density lipoprotein receptor.	0.461
NID1	NID2	ENSECAP00000014454	ENSECAP00000035822	Nidogen 1.	Nidogen 2.	0.512
NID2	NID1	ENSECAP00000035822	ENSECAP00000014454	Nidogen 2.	Nidogen 1.	0.512
VLDLR	LRP2	ENSECAP00000028774	ENSECAP00000040585	Very low density lipoprotein receptor.	LDL receptor related protein 2.	0.428
VLDLR	LRP8	ENSECAP00000028774	ENSECAP00000054730	Very low density lipoprotein receptor.	LDL receptor related protein 8.	0.461