STRINGSTRING
GAS6 GAS6 TMEM8B TMEM8B HEG1 HEG1 MATN2 MATN2 VASN VASN SCUBE1 SCUBE1 CLEC14A CLEC14A EYS EYS THBD THBD F7 F7 MUC13 MUC13 SLIT3 SLIT3 TIE1 TIE1 ADAM9 ADAM9 EREG EREG DLL3 DLL3 LRP6 LRP6 MALRD1 MALRD1 NPNT NPNT MATN1 MATN1 SELE SELE OIT3 OIT3 EGFL8 EGFL8 EGFL6 EGFL6 FBLN2 FBLN2 MEP1B MEP1B THBS1 THBS1 ATRNL1 ATRNL1 SCUBE2 SCUBE2 F12 F12 VWCE VWCE TGFA TGFA STAB1 STAB1 EGF EGF SELP SELP MMRN1 MMRN1 DLK2 DLK2 NAGPA NAGPA THBS3 THBS3 CNTNAP4 CNTNAP4 NOTCH4 NOTCH4 CLEC18B CLEC18B SLIT1 SLIT1 FAT4 FAT4 DLL4 DLL4 FAT1 FAT1 JAG1 JAG1 UMOD UMOD FBN2 FBN2 DLL1 DLL1 CRELD1 CRELD1 ADAM28 ADAM28 STAB2 STAB2 F10 F10 EDIL3 EDIL3 NCAN NCAN CD93 CD93 SCUBE3 SCUBE3 CELSR3 CELSR3 NID1 NID1 ZAN ZAN MATN3 MATN3 TEK TEK CUBN CUBN PTGS2 PTGS2 MATN4 MATN4 CELSR2 CELSR2 HYAL3 HYAL3 ADAM23 ADAM23 TDGF1 TDGF1 AREL1 AREL1 ITGB8 ITGB8 MEGF8 MEGF8 FBN1 FBN1 RSPO3 RSPO3 SELL SELL THBS4 THBS4 TENM1 TENM1 LTBP1 LTBP1 SCARF1 SCARF1 FBLN7 FBLN7 TMEFF2 TMEFF2 CRELD2 CRELD2 F9 F9 TMEM8A TMEM8A CRB2 CRB2 VWDE VWDE PEAR1 PEAR1 RELN RELN THBS2 THBS2 GPR179 GPR179 NOTCH3 NOTCH3 SVEP1 SVEP1 LOC100056890 LOC100056890 AREG AREG HABP2 HABP2 NOTCH1 NOTCH1 LOC106783049 LOC106783049 LRP4 LRP4 ADAM33 ADAM33 ADAM11 ADAM11 CNTNAP1 CNTNAP1 ADAM18 ADAM18 HHIP HHIP BRINP2 BRINP2 SNED1 SNED1 PROZ PROZ NELL1 NELL1 MEGF10 MEGF10 WIF1 WIF1 LOC100067905 LOC100067905 CNTNAP5 CNTNAP5 CNTNAP2 CNTNAP2 NRG4 NRG4 LOC100057011 LOC100057011 ENSECAP00000023688 ENSECAP00000023688 SCARF2 SCARF2 BCAN BCAN HYAL4 HYAL4 NRXN3 NRXN3 ADGRE1 ADGRE1 HBEGF HBEGF FBN3 FBN3 FBLN1 FBLN1 NRXN2 NRXN2 FAT2 FAT2 NTNG2 NTNG2 PROC PROC LTBP3 LTBP3 THSD7A THSD7A VLDLR VLDLR TENM4 TENM4 VWA2 VWA2 SORL1 SORL1 PROS1 PROS1 NRG2 NRG2 LOC100053748 LOC100053748 CD248 CD248 EGFLAM EGFLAM ENSECAP00000030956 ENSECAP00000030956 ADAM30 ADAM30 HGFAC HGFAC MEGF11 MEGF11 ENSECAP00000032288 ENSECAP00000032288 LTBP4 LTBP4 DNER DNER LOC100057592 LOC100057592 ADAM15 ADAM15 TENM3 TENM3 LRP1B LRP1B ASTN1 ASTN1 NID2 NID2 AGRN AGRN ITGB5 ITGB5 DLK1 DLK1 ITGBL1 ITGBL1 LRP5 LRP5 COMP COMP ADAM8 ADAM8 TNC TNC LAMA5 LAMA5 CCBE1 CCBE1 UMODL1 UMODL1 NELL2 NELL2 LOC111774822 LOC111774822 ADAM22 ADAM22 LRP2 LRP2 JAG2 JAG2 MEGF6 MEGF6 SLIT2 SLIT2 CELSR1 CELSR1 PAMR1 PAMR1 ADGRL4 ADGRL4 SUSD1 SUSD1 LRP1 LRP1 LOC100064076 LOC100064076 LOC100630731 LOC100630731 TNN TNN LOC100053318 LOC100053318 NOTCH2 NOTCH2 PLAT PLAT MUC4 MUC4 MEP1A MEP1A EGFL7 EGFL7 BTC BTC EFEMP2 EFEMP2 CRB1 CRB1 NRXN1 NRXN1 FAT3 FAT3 LOC100064538 LOC100064538 ENSECAP00000051748 ENSECAP00000051748 NTNG1 NTNG1 VCAN VCAN LDLR LDLR ATRN ATRN MSANTD3-TMEFF1 MSANTD3-TMEFF1 TENM2 TENM2 EPGN EPGN CSPG5 CSPG5 HSPG2 HSPG2 LRP8 LRP8 NRG3 NRG3 ATRAID ATRAID PCSK6 PCSK6 NRG1 NRG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAS6Growth arrest specific 6. (646 aa)
TMEM8BTransmembrane protein 8B. (534 aa)
HEG1Heart development protein with EGF like domains 1. (1365 aa)
MATN2Matrilin 2. (971 aa)
VASNVasorin. (752 aa)
SCUBE1Signal peptide, CUB domain and EGF like domain containing 1. (1018 aa)
CLEC14AC-type lectin domain containing 14A. (500 aa)
EYSEyes shut homolog. (3137 aa)
THBDThrombomodulin. (559 aa)
F7Coagulation factor VII. (446 aa)
MUC13Uncharacterized protein. (466 aa)
SLIT3Slit guidance ligand 3. (1521 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1139 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
EREGEpiregulin. (170 aa)
DLL3Delta like canonical Notch ligand 3. (619 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
MALRD1MAM and LDL receptor class A domain containing 1. (2156 aa)
NPNTNephronectin. (618 aa)
MATN1Matrilin 1. (521 aa)
SELEE-selectin; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis (By similarity). Belongs to the selectin/LECAM family. (617 aa)
OIT3Oncoprotein induced transcript 3. (546 aa)
EGFL8EGF like domain multiple 8. (295 aa)
EGFL6EGF like domain multiple 6. (642 aa)
FBLN2Fibulin 2. (1230 aa)
MEP1BMeprin A subunit. (700 aa)
THBS1Thrombospondin 1. (1170 aa)
ATRNL1Attractin like 1. (1380 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (993 aa)
F12Coagulation factor XII. (615 aa)
VWCEVon Willebrand factor C and EGF domains. (970 aa)
TGFATransforming growth factor alpha. (221 aa)
STAB1Stabilin 1. (2572 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
SELPSelectin P. (829 aa)
MMRN1Multimerin 1. (1223 aa)
DLK2Delta like non-canonical Notch ligand 2. (383 aa)
NAGPAN-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (569 aa)
THBS3Thrombospondin 3. (956 aa)
CNTNAP4Contactin associated protein like 4. (1322 aa)
NOTCH4Notch receptor 4. (2021 aa)
CLEC18BUncharacterized protein. (451 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
FAT4FAT atypical cadherin 4. (5113 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
FAT1FAT atypical cadherin 1. (4590 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
UMODUromodulin. (644 aa)
FBN2Fibrillin 2. (2912 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
CRELD1Cysteine rich with EGF like domains 1. (432 aa)
ADAM28ADAM metallopeptidase domain 28. (819 aa)
STAB2Stabilin 2. (2549 aa)
F10Coagulation factor X. (491 aa)
EDIL3EGF like repeats and discoidin domains 3. (481 aa)
NCANNeurocan. (1365 aa)
CD93CD93 molecule. (648 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (993 aa)
CELSR3Cadherin EGF LAG seven-pass G-type receptor 3; Belongs to the G-protein coupled receptor 2 family. (3316 aa)
NID1Nidogen 1. (1244 aa)
ZANZonadhesin. (2562 aa)
MATN3Matrilin 3. (475 aa)
TEKTEK receptor tyrosine kinase. (1153 aa)
CUBNCubilin. (3615 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (666 aa)
MATN4Matrilin 4. (621 aa)
CELSR2Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2923 aa)
HYAL3Hyaluronidase. (415 aa)
ADAM23ADAM metallopeptidase domain 23. (833 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
AREL1Latent transforming growth factor beta binding protein 2. (1819 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
FBN1Fibrillin 1. (3030 aa)
RSPO3R-spondin 3. (288 aa)
SELLSelectin L. (496 aa)
THBS4Thrombospondin 4. (961 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1715 aa)
SCARF1Scavenger receptor class F member 1. (830 aa)
FBLN7Fibulin 7. (467 aa)
TMEFF2Transmembrane protein with EGF like and two follistatin like domains 2. (374 aa)
CRELD2Cysteine rich with EGF like domains 2. (356 aa)
F9Coagulation factor IX. (457 aa)
TMEM8ATransmembrane protein 8A. (767 aa)
CRB2Crumbs cell polarity complex component 2. (1286 aa)
VWDEVon Willebrand factor D and EGF domains. (1830 aa)
PEAR1Platelet endothelial aggregation receptor 1. (1049 aa)
RELNReelin. (3460 aa)
THBS2Thrombospondin 2. (1172 aa)
GPR179G protein-coupled receptor 179. (2380 aa)
NOTCH3Notch receptor 3. (2458 aa)
SVEP1Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1. (3602 aa)
LOC100056890Uncharacterized protein. (723 aa)
AREGAmphiregulin. (247 aa)
HABP2Hyaluronan binding protein 2. (611 aa)
NOTCH1Notch receptor 1. (2581 aa)
LOC106783049Hyaluronidase. (496 aa)
LRP4LDL receptor related protein 4. (1905 aa)
ADAM33ADAM metallopeptidase domain 33. (791 aa)
ADAM11ADAM metallopeptidase domain 11. (771 aa)
CNTNAP1Contactin associated protein 1. (1386 aa)
ADAM18ADAM metallopeptidase domain 18. (739 aa)
HHIPHedgehog interacting protein. (700 aa)
BRINP2BMP/retinoic acid inducible neural specific 2. (783 aa)
SNED1Sushi, nidogen and EGF like domains 1. (1587 aa)
PROZProtein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family. (400 aa)
NELL1Neural EGFL like 1. (911 aa)
MEGF10Multiple EGF like domains 10. (1178 aa)
WIF1WNT inhibitory factor 1. (379 aa)
LOC100067905EGF-like domain-containing protein. (196 aa)
CNTNAP5Contactin associated protein like 5. (1307 aa)
CNTNAP2Contactin associated protein like 2. (1330 aa)
NRG4Neuregulin 4. (116 aa)
LOC100057011Uncharacterized protein. (746 aa)
ENSECAP00000023688Uncharacterized protein. (2180 aa)
SCARF2Scavenger receptor class F member 2. (1167 aa)
BCANBrevican. (981 aa)
HYAL4Hyaluronidase. (481 aa)
NRXN3Neurexin 3. (1664 aa)
ADGRE1Adhesion G protein-coupled receptor E1; Belongs to the G-protein coupled receptor 2 family. (1233 aa)
HBEGFHeparin binding EGF like growth factor. (390 aa)
FBN3Fibrillin 3. (2784 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (753 aa)
NRXN2Neurexin 2. (1802 aa)
FAT2FAT atypical cadherin 2. (4351 aa)
NTNG2Netrin G2. (634 aa)
PROCVitamin K-dependent protein C; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (640 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1554 aa)
THSD7AThrombospondin type 1 domain containing 7A. (1650 aa)
VLDLRVery low density lipoprotein receptor. (1140 aa)
TENM4Teneurin transmembrane protein 4. (2866 aa)
VWA2Von Willebrand factor A domain containing 2. (883 aa)
SORL1Sortilin related receptor 1. (2255 aa)
PROS1Protein S. (912 aa)
NRG2Neuregulin 2. (923 aa)
LOC100053748Uncharacterized protein. (740 aa)
CD248CD248 molecule. (773 aa)
EGFLAMEGF like, fibronectin type III and laminin G domains. (1017 aa)
ENSECAP00000030956Uncharacterized protein. (732 aa)
ADAM30ADAM metallopeptidase domain 30. (713 aa)
HGFACHGF activator. (719 aa)
MEGF11Multiple EGF like domains 11. (1140 aa)
ENSECAP00000032288Uncharacterized protein. (465 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1708 aa)
DNERDelta/notch like EGF repeat containing. (734 aa)
LOC100057592Uncharacterized protein. (698 aa)
ADAM15ADAM metallopeptidase domain 15. (970 aa)
TENM3Teneurin transmembrane protein 3. (2699 aa)
LRP1BLDL receptor related protein 1B. (4599 aa)
ASTN1Astrotactin 1. (1335 aa)
NID2Nidogen 2. (1359 aa)
AGRNAgrin. (2071 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (837 aa)
DLK1Delta like non-canonical Notch ligand 1. (438 aa)
ITGBL1Integrin subunit beta like 1. (556 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
COMPCartilage oligomeric matrix protein. (793 aa)
ADAM8Uncharacterized protein. (824 aa)
TNCTenascin C. (2293 aa)
LAMA5Laminin subunit alpha 5. (3696 aa)
CCBE1Collagen and calcium binding EGF domains 1. (439 aa)
UMODL1Uromodulin like 1. (1358 aa)
NELL2Neural EGFL like 2. (1038 aa)
LOC111774822Uncharacterized protein. (793 aa)
ADAM22ADAM metallopeptidase domain 22. (982 aa)
LRP2LDL receptor related protein 2. (4673 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1240 aa)
MEGF6Multiple EGF like domains 6. (1670 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3076 aa)
PAMR1Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family. (875 aa)
ADGRL4Adhesion G protein-coupled receptor L4; Belongs to the G-protein coupled receptor 2 family. (739 aa)
SUSD1Sushi domain containing 1. (835 aa)
LRP1LDL receptor related protein 1. (4567 aa)
LOC100064076Uncharacterized protein. (1308 aa)
LOC100630731Uncharacterized protein. (743 aa)
TNNTenascin N. (1296 aa)
LOC100053318Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (711 aa)
NOTCH2Notch receptor 2. (2471 aa)
PLATPlasminogen activator, tissue type. (615 aa)
MUC4Uncharacterized protein. (1173 aa)
MEP1AMeprin A subunit. (773 aa)
EGFL7EGF like domain multiple 7. (344 aa)
BTCBetacellulin. (188 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (517 aa)
CRB1Crumbs cell polarity complex component 1. (1377 aa)
NRXN1Neurexin 1. (1507 aa)
FAT3FAT atypical cadherin 3. (4612 aa)
LOC100064538Uncharacterized protein. (788 aa)
ENSECAP00000051748Uncharacterized protein. (1544 aa)
NTNG1Netrin G1. (581 aa)
VCANVersican. (3400 aa)
LDLRLow density lipoprotein receptor. (937 aa)
ATRNAttractin. (1417 aa)
MSANTD3-TMEFF1MSANTD3-TMEFF1 readthrough. (485 aa)
TENM2Teneurin transmembrane protein 2. (2764 aa)
EPGNEpithelial mitogen. (154 aa)
CSPG5SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1681 aa)
HSPG2Heparan sulfate proteoglycan 2. (4395 aa)
LRP8LDL receptor related protein 8. (1011 aa)
NRG3Neuregulin 3. (727 aa)
ATRAIDAll-trans retinoic acid induced differentiation factor. (229 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (975 aa)
NRG1Neuregulin 1. (712 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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