(8 nodes) Phosphotyrosine-binding domain (IRS1-like) network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DOK3	Docking protein 3. (442 aa)
	LOC100069009	Uncharacterized protein. (571 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (515 aa)
	DOK2	Docking protein 2. (521 aa)
	DOK1	Docking protein 1. (481 aa)
	IRS4	Insulin receptor substrate 4. (1355 aa)
	IRS1	Insulin receptor substrate 1. (1239 aa)
	IRS2	Insulin receptor substrate 2. (1401 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FRS2	IRS2	ENSECAP00000038097	ENSECAP00000002251	Fibroblast growth factor receptor substrate 2.	Insulin receptor substrate 2.	0.506
IRS1	IRS2	ENSECAP00000005422	ENSECAP00000002251	Insulin receptor substrate 1.	Insulin receptor substrate 2.	0.917
IRS1	IRS4	ENSECAP00000005422	ENSECAP00000009452	Insulin receptor substrate 1.	Insulin receptor substrate 4.	0.543
IRS2	FRS2	ENSECAP00000002251	ENSECAP00000038097	Insulin receptor substrate 2.	Fibroblast growth factor receptor substrate 2.	0.506
IRS2	IRS1	ENSECAP00000002251	ENSECAP00000005422	Insulin receptor substrate 2.	Insulin receptor substrate 1.	0.917
IRS2	IRS4	ENSECAP00000002251	ENSECAP00000009452	Insulin receptor substrate 2.	Insulin receptor substrate 4.	0.551
IRS4	IRS1	ENSECAP00000009452	ENSECAP00000005422	Insulin receptor substrate 4.	Insulin receptor substrate 1.	0.543
IRS4	IRS2	ENSECAP00000009452	ENSECAP00000002251	Insulin receptor substrate 4.	Insulin receptor substrate 2.	0.551
IRS4	LOC100069009	ENSECAP00000009452	ENSECAP00000038151	Insulin receptor substrate 4.	Uncharacterized protein.	0.416
LOC100069009	IRS4	ENSECAP00000038151	ENSECAP00000009452	Uncharacterized protein.	Insulin receptor substrate 4.	0.416