STRINGSTRING
ADGRA3 ADGRA3 RXFP1 RXFP1 TLR9 TLR9 LRRD1 LRRD1 LRRC4B LRRC4B RXFP2 RXFP2 LRRN3 LRRN3 PODN PODN LRTM2 LRTM2 LGI2 LGI2 OMG OMG RSU1 RSU1 MXRA5 MXRA5 FLII FLII TLR2 TLR2 LRRC26 LRRC26 LOC100058594 LOC100058594 LRIG2 LRIG2 CNOT6 CNOT6 LRRC57 LRRC57 LRRC2 LRRC2 LRRC32 LRRC32 LGI3 LGI3 SLITRK2 SLITRK2 LRIG3 LRIG3 LRRN4 LRRN4 LGI4 LGI4 LRRC39 LRRC39 LRRC63 LRRC63 LRRC4C LRRC4C LRRC47 LRRC47 CHAD CHAD IGSF10 IGSF10 LRRK1 LRRK1 LRRC24 LRRC24 LGI1 LGI1 LRFN4 LRFN4 LRRC40 LRRC40 TLR7 TLR7 FLRT1 FLRT1 TRIL TRIL LINGO3 LINGO3 LRCH4 LRCH4 PODNL1 PODNL1 SLITRK4 SLITRK4 LRFN3 LRFN3 FMOD FMOD ISLR2 ISLR2 TLR3 TLR3 PIDD1 PIDD1 SLITRK5 SLITRK5 LOC111771935 LOC111771935 ENSECAP00000036381 ENSECAP00000036381 GP1BA GP1BA LRRC66 LRRC66 IGFALS IGFALS LRWD1 LRWD1 LRIT3 LRIT3 TLR5 TLR5 PXDN PXDN LRFN2 LRFN2 BGN BGN LRG1 LRG1 SLIT2 SLIT2 PKD1 PKD1 LRFN5 LRFN5 MFHAS1 MFHAS1 RTN4RL2 RTN4RL2 ENSECAP00000045503 ENSECAP00000045503 NYX NYX LRIG1 LRIG1 LRRC28 LRRC28 LRCH1 LRCH1 AP1G1 AP1G1 LRRC3B LRRC3B CHADL CHADL LINGO2 LINGO2 LRRTM4 LRRTM4 SCRIB SCRIB LRIT2 LRIT2 LRCH2 LRCH2 LRRC53 LRRC53 LGR4 LGR4 LRRC8A LRRC8A SLITRK6 SLITRK6 SLIT1 SLIT1 SHOC2 SHOC2 LINGO4 LINGO4 LGR6 LGR6 LGR5 LGR5 LRR1 LRR1 LRRC8C LRRC8C LRTM1 LRTM1 LOC100072794 LOC100072794 TLR4 TLR4 TLR8 TLR8 FLRT2 FLRT2 LRRTM1 LRRTM1 LRFN1 LRFN1 LRRTM2 LRRTM2 SLIT3 SLIT3 LOC100072493 LOC100072493 LRRC8D LRRC8D TSKU TSKU LRRN2 LRRN2 LINGO1 LINGO1 LOC100069988 LOC100069988 LRRC3 LRRC3 AMIGO3 AMIGO3 LRRC15 LRRC15 CPN2 CPN2 RTN4R RTN4R RTN4RL1 RTN4RL1 VASN VASN ISLR ISLR LRIT1 LRIT1 AMIGO1 AMIGO1 GP5 GP5 LRRC4 LRRC4 LRRN1 LRRN1 LRRC30 LRRC30 SLITRK1 SLITRK1 LRRC3C LRRC3C FLRT3 FLRT3 LRRTM3 LRRTM3 LRRC27 LRRC27 NRROS NRROS LRRC8E LRRC8E SLITRK3 SLITRK3 ADGRA2 ADGRA2 LRRC58 LRRC58
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADGRA3Adhesion G protein-coupled receptor A3; Belongs to the G-protein coupled receptor 2 family. (1313 aa)
RXFP1Relaxin family peptide receptor 1. (785 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
LRRD1Leucine rich repeats and death domain containing 1. (870 aa)
LRRC4BLeucine rich repeat containing 4B. (713 aa)
RXFP2Relaxin family peptide receptor 2. (739 aa)
LRRN3Leucine rich repeat neuronal 3. (708 aa)
PODNPodocan. (617 aa)
LRTM2Leucine rich repeats and transmembrane domains 2. (370 aa)
LGI2Leucine rich repeat LGI family member 2. (547 aa)
OMGOligodendrocyte myelin glycoprotein. (443 aa)
RSU1Ras suppressor protein 1. (296 aa)
MXRA5Matrix remodeling associated 5. (2851 aa)
FLIIFLII actin remodeling protein. (1270 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
LRRC26Leucine rich repeat containing 26. (329 aa)
LOC100058594Uncharacterized protein. (629 aa)
LRIG2Leucine rich repeats and immunoglobulin like domains 2. (1023 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (557 aa)
LRRC57Leucine rich repeat containing 57. (239 aa)
LRRC2Leucine rich repeat containing 2. (370 aa)
LRRC32Leucine rich repeat containing 32. (745 aa)
LGI3Leucine rich repeat LGI family member 3. (548 aa)
SLITRK2SLIT and NTRK like family member 2. (845 aa)
LRIG3Leucine rich repeats and immunoglobulin like domains 3. (1122 aa)
LRRN4Leucine rich repeat neuronal 4. (739 aa)
LGI4Leucine rich repeat LGI family member 4. (537 aa)
LRRC39Leucine rich repeat containing 39. (335 aa)
LRRC63Leucine rich repeat containing 63. (572 aa)
LRRC4CLeucine rich repeat containing 4C. (640 aa)
LRRC47Leucine rich repeat containing 47. (644 aa)
CHADChondroadherin. (359 aa)
IGSF10Immunoglobulin superfamily member 10. (2611 aa)
LRRK1Leucine rich repeat kinase 1. (2014 aa)
LRRC24Leucine rich repeat containing 24. (610 aa)
LGI1Leucine rich glioma inactivated 1. (641 aa)
LRFN4Leucine rich repeat and fibronectin type III domain containing 4. (636 aa)
LRRC40Leucine rich repeat containing 40. (602 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1054 aa)
FLRT1Fibronectin leucine rich transmembrane protein 1. (674 aa)
TRILTLR4 interactor with leucine rich repeats. (810 aa)
LINGO3Leucine rich repeat and Ig domain containing 3. (592 aa)
LRCH4Leucine rich repeats and calponin homology domain containing 4. (744 aa)
PODNL1Podocan like 1. (574 aa)
SLITRK4SLIT and NTRK like family member 4. (1013 aa)
LRFN3Leucine rich repeat and fibronectin type III domain containing 3. (628 aa)
FMODFibromodulin. (392 aa)
ISLR2Immunoglobulin superfamily containing leucine rich repeat 2. (763 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
PIDD1P53-induced death domain protein 1. (915 aa)
SLITRK5SLIT and NTRK like family member 5. (958 aa)
LOC111771935Toll-like receptor 4. (843 aa)
ENSECAP00000036381TIR domain-containing protein; Belongs to the Toll-like receptor family. (772 aa)
GP1BAGlycoprotein Ib platelet subunit alpha. (608 aa)
LRRC66Leucine rich repeat containing 66. (1060 aa)
IGFALSInsulin like growth factor binding protein acid labile subunit. (605 aa)
LRWD1Leucine rich repeats and WD repeat domain containing 1. (745 aa)
LRIT3Leucine rich repeat, Ig-like and transmembrane domains 3. (680 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (867 aa)
PXDNPeroxidasin. (1596 aa)
LRFN2Leucine rich repeat and fibronectin type III domain containing 2. (817 aa)
BGNBiglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (460 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4267 aa)
LRFN5Leucine rich repeat and fibronectin type III domain containing 5. (775 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1046 aa)
RTN4RL2Reticulon 4 receptor like 2. (420 aa)
ENSECAP00000045503Endo/exonuclease/phosphatase domain-containing protein. (538 aa)
NYXNyctalopin. (484 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1094 aa)
LRRC28Leucine rich repeat containing 28. (394 aa)
LRCH1Leucine rich repeats and calponin homology domain containing 1. (763 aa)
AP1G1PH domain and leucine rich repeat protein phosphatase 2. (2139 aa)
LRRC3BLeucine rich repeat containing 3B. (259 aa)
CHADLChondroadherin like. (766 aa)
LINGO2Uncharacterized protein. (606 aa)
LRRTM4Leucine rich repeat transmembrane neuronal 4. (591 aa)
SCRIBScribble planar cell polarity protein. (1690 aa)
LRIT2Leucine rich repeat, Ig-like and transmembrane domains 2. (556 aa)
LRCH2Leucine rich repeats and calponin homology domain containing 2. (764 aa)
LRRC53Leucine rich repeat containing 53. (1245 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (1108 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
SLITRK6SLIT and NTRK like family member 6. (869 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
SHOC2SHOC2 leucine rich repeat scaffold protein. (582 aa)
LINGO4Leucine rich repeat and Ig domain containing 4. (666 aa)
LGR6Leucine rich repeat containing G protein-coupled receptor 6. (965 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
LRR1Leucine rich repeat protein 1. (413 aa)
LRRC8CLeucine rich repeat containing 8 VRAC subunit B. (803 aa)
LRTM1Leucine rich repeats and transmembrane domains 1. (339 aa)
LOC100072794Uncharacterized protein. (557 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1038 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (660 aa)
LRRTM1Leucine rich repeat transmembrane neuronal 1. (522 aa)
LRFN1Leucine rich repeat and fibronectin type III domain containing 1. (770 aa)
LRRTM2Leucine rich repeat transmembrane neuronal 2. (516 aa)
SLIT3Slit guidance ligand 3. (1521 aa)
LOC100072493TIR domain-containing protein. (976 aa)
LRRC8DLeucine rich repeat containing 8 VRAC subunit D. (861 aa)
TSKUTsukushi, small leucine rich proteoglycan. (551 aa)
LRRN2Leucine rich repeat neuronal 2. (712 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (620 aa)
LOC100069988TIR domain-containing protein. (949 aa)
LRRC3Leucine rich repeat containing 3. (257 aa)
AMIGO3Adhesion molecule with Ig like domain 3. (510 aa)
LRRC15Leucine rich repeat containing 15. (618 aa)
CPN2Carboxypeptidase N subunit 2. (547 aa)
RTN4RReticulon 4 receptor. (473 aa)
RTN4RL1Reticulon 4 receptor like 1. (445 aa)
VASNVasorin. (752 aa)
ISLRImmunoglobulin superfamily containing leucine rich repeat. (428 aa)
LRIT1Leucine rich repeat, Ig-like and transmembrane domains 1. (621 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (493 aa)
GP5Glycoprotein V platelet. (511 aa)
LRRC4Leucine rich repeat containing 4. (652 aa)
LRRN1Leucine rich repeat neuronal 1. (716 aa)
LRRC30Leucine rich repeat containing 30. (301 aa)
SLITRK1SLIT and NTRK like family member 1. (696 aa)
LRRC3CLeucine rich repeat containing 3C. (254 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (610 aa)
LRRTM3Leucine rich repeat transmembrane neuronal 3. (581 aa)
LRRC27Leucine rich repeat containing 27. (521 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
LRRC8ELeucine rich repeat containing 8 VRAC subunit E. (793 aa)
SLITRK3SLIT and NTRK like family member 3. (976 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1338 aa)
LRRC58Leucine rich repeat containing 58. (371 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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