(19 nodes) Arginine biosynthesis network (Equus caballus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	GOT1	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (423 aa)
	ASS1	Argininosuccinate synthase 1. (509 aa)
	GLS2	Glutaminase 2. (602 aa)
	GPT2	Glutamic--pyruvic transaminase 2. (523 aa)
	ACY1	M20_dimer domain-containing protein. (465 aa)
	GLS	Glutaminase. (673 aa)
	NAGS	N-acetylglutamate synthase. (529 aa)
	GPT	Glutamic--pyruvic transaminase. (496 aa)
	GOT1L1	Glutamic-oxaloacetic transaminase 1 like 1. (416 aa)
	ARG2	Arginase. (351 aa)
	GOT2	Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). (430 aa)
	OTC	Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
	ARG1	Arginase. (348 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1267 aa)
	GLUL	Glutamine synthetase. (373 aa)
	ASL	Argininosuccinate lyase. (660 aa)
	NOS1	Nitric oxide synthase 1. (1468 aa)
	GLUD1	ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (558 aa)
	CPS1	Carbamoyl-phosphate synthase 1. (1521 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACY1	ARG1	ENSECAP00000008546	ENSECAP00000021081	M20_dimer domain-containing protein.	Arginase.	0.922
ACY1	ARG2	ENSECAP00000008546	ENSECAP00000014452	M20_dimer domain-containing protein.	Arginase.	0.922
ACY1	ASL	ENSECAP00000008546	ENSECAP00000030718	M20_dimer domain-containing protein.	Argininosuccinate lyase.	0.521
ACY1	ASS1	ENSECAP00000008546	ENSECAP00000005493	M20_dimer domain-containing protein.	Argininosuccinate synthase 1.	0.832
ACY1	CPS1	ENSECAP00000008546	ENSECAP00000050225	M20_dimer domain-containing protein.	Carbamoyl-phosphate synthase 1.	0.477
ACY1	GLS2	ENSECAP00000008546	ENSECAP00000007422	M20_dimer domain-containing protein.	Glutaminase 2.	0.490
ACY1	NAGS	ENSECAP00000008546	ENSECAP00000011044	M20_dimer domain-containing protein.	N-acetylglutamate synthase.	0.424
ACY1	OTC	ENSECAP00000008546	ENSECAP00000020428	M20_dimer domain-containing protein.	Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily.	0.974
ARG1	ACY1	ENSECAP00000021081	ENSECAP00000008546	Arginase.	M20_dimer domain-containing protein.	0.922
ARG1	ARG2	ENSECAP00000021081	ENSECAP00000014452	Arginase.	Arginase.	0.910
ARG1	ASL	ENSECAP00000021081	ENSECAP00000030718	Arginase.	Argininosuccinate lyase.	0.978
ARG1	ASS1	ENSECAP00000021081	ENSECAP00000005493	Arginase.	Argininosuccinate synthase 1.	0.596
ARG1	CPS1	ENSECAP00000021081	ENSECAP00000050225	Arginase.	Carbamoyl-phosphate synthase 1.	0.550
ARG1	GLUD1	ENSECAP00000021081	ENSECAP00000044983	Arginase.	ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.425
ARG1	GLUL	ENSECAP00000021081	ENSECAP00000029046	Arginase.	Glutamine synthetase.	0.526
ARG1	GOT1	ENSECAP00000021081	ENSECAP00000000135	Arginase.	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...]	0.408
ARG1	GOT2	ENSECAP00000021081	ENSECAP00000014550	Arginase.	Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity).	0.406
ARG1	NAGS	ENSECAP00000021081	ENSECAP00000011044	Arginase.	N-acetylglutamate synthase.	0.580
ARG1	NOS1	ENSECAP00000021081	ENSECAP00000038208	Arginase.	Nitric oxide synthase 1.	0.927
ARG1	NOS3	ENSECAP00000021081	ENSECAP00000022325	Arginase.	Nitric oxide synthase; Produces nitric oxide (NO).	0.940