STRINGSTRING
GOT1 GOT1 MAOB MAOB P4HA3 P4HA3 SAT2 SAT2 AGMAT AGMAT DAO DAO CKB CKB GAMT GAMT ALDH7A1 ALDH7A1 GATM GATM OAT OAT GOT1L1 GOT1L1 ARG2 ARG2 GOT2 GOT2 ALDH18A1 ALDH18A1 SMS SMS L3HYPDH L3HYPDH ALDH2 ALDH2 PYCR3 PYCR3 SRM SRM SAT1 SAT1 ODC1 ODC1 AZIN2 AZIN2 CNDP1 CNDP1 LOC100056283 LOC100056283 ARG1 ARG1 ALDH16A1 ALDH16A1 CKMT2 CKMT2 NOS3 NOS3 LOC100050480 LOC100050480 PYCR2 PYCR2 ALDH3A2 ALDH3A2 P4HA2 P4HA2 LAP3 LAP3 NOS1 NOS1 LOC111772327 LOC111772327 AOC1 AOC1 PRODH2 PRODH2 AMD1 AMD1 MAOA MAOA P4HA1 P4HA1 TMCO1 TMCO1 CKM CKM CARNS1 CARNS1 PYCR1 PYCR1 HOGA1 HOGA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GOT1Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (423 aa)
MAOBAmine oxidase. (520 aa)
P4HA3Prolyl 4-hydroxylase subunit alpha 3. (544 aa)
SAT2Spermidine/spermine N1-acetyltransferase family member 2. (170 aa)
AGMATAgmatinase; Belongs to the arginase family. (364 aa)
DAOD-amino acid oxidase. (361 aa)
CKBCreatine kinase B; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
GAMTGuanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. (236 aa)
ALDH7A1Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (566 aa)
GATMGlycine amidinotransferase. (473 aa)
OATOrnithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa)
GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (416 aa)
ARG2Arginase. (351 aa)
GOT2Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). (430 aa)
ALDH18A1Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa)
SMSSpermine synthase. (365 aa)
L3HYPDHTrans-L-3-hydroxyproline dehydratase. (354 aa)
ALDH2Aldehyde dehydrogenase, mitochondrial; Belongs to the aldehyde dehydrogenase family. (625 aa)
PYCR3Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (275 aa)
SRMSpermidine synthase; Belongs to the spermidine/spermine synthase family. (302 aa)
SAT1Spermidine/spermine N1-acetyltransferase 1. (171 aa)
ODC1Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (489 aa)
AZIN2Antizyme inhibitor 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (577 aa)
CNDP1Carnosine dipeptidase 1. (506 aa)
LOC100056283Uncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (417 aa)
ARG1Arginase. (348 aa)
ALDH16A1Aldehyde dehydrogenase family 16 member A1. (803 aa)
CKMT2Creatine kinase, mitochondrial 2; Belongs to the ATP:guanido phosphotransferase family. (567 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1267 aa)
LOC100050480Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (599 aa)
PYCR2Uncharacterized protein. (350 aa)
ALDH3A2Aldehyde dehydrogenase 3 family member A2; Belongs to the aldehyde dehydrogenase family. (595 aa)
P4HA2Prolyl 4-hydroxylase subunit alpha 2. (617 aa)
LAP3Leucine aminopeptidase 3. (545 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
LOC111772327Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (328 aa)
AOC1Amine oxidase. (793 aa)
PRODH2Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (460 aa)
AMD1S-adenosylmethionine decarboxylase proenzyme. (334 aa)
MAOAAmine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). (922 aa)
P4HA1Prolyl 4-hydroxylase subunit alpha 1. (534 aa)
TMCO1Aldehyde dehydrogenase 9 family member A1; Belongs to the aldehyde dehydrogenase family. (565 aa)
CKMCreatine kinase, M-type; Belongs to the ATP:guanido phosphotransferase family. (385 aa)
CARNS1Carnosine synthase 1. (953 aa)
PYCR1Pyrroline-5-carboxylate reductase 1. (445 aa)
HOGA14-hydroxy-2-oxoglutarate aldolase 1. (353 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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