22 items (Equus caballus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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Predicted Interactions

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protein homology

Your Input:
	HMGCS2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
	PCYOX1L	Prenylcysteine oxidase 1 like. (503 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
	NUS1	NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
	ACAT2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	PCYOX1	Prenylcysteine oxidase 1. (504 aa)
	PMVK	Phosphomevalonate kinase. (192 aa)
	DHDDS	Alkyl transferase; Belongs to the UPP synthase family. (383 aa)
	GGPS1	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (299 aa)
	FNTA	Farnesyltransferase, CAAX box, alpha. (379 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
	PDSS1	Decaprenyl diphosphate synthase subunit 1; Belongs to the FPP/GGPP synthase family. (408 aa)
	ICMT	Protein-S-isoprenylcysteine O-methyltransferase. (296 aa)
	IDI1	Isopentenyl-diphosphate delta isomerase 1. (227 aa)
	PDSS2	Decaprenyl diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (410 aa)
	MVK	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (541 aa)
	RCE1	Ras converting CAAX endopeptidase 1. (590 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (901 aa)
	FNTB	Protein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. (513 aa)
	MVD	Mevalonate diphosphate decarboxylase. (497 aa)
	FDPS	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (420 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAT1	ACAT2	ENSECAP00000017849	ENSECAP00000012443	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.913
ACAT1	HMGCR	ENSECAP00000017849	ENSECAP00000042219	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.404
ACAT1	HMGCS1	ENSECAP00000017849	ENSECAP00000006800	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.990
ACAT1	HMGCS2	ENSECAP00000017849	ENSECAP00000000412	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.991
ACAT1	MVD	ENSECAP00000017849	ENSECAP00000053047	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Mevalonate diphosphate decarboxylase.	0.524
ACAT1	MVK	ENSECAP00000017849	ENSECAP00000031677	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.677
ACAT2	ACAT1	ENSECAP00000012443	ENSECAP00000017849	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.913
ACAT2	FDPS	ENSECAP00000012443	ENSECAP00000053191	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.459
ACAT2	HMGCR	ENSECAP00000012443	ENSECAP00000042219	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.647
ACAT2	HMGCS1	ENSECAP00000012443	ENSECAP00000006800	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.995
ACAT2	HMGCS2	ENSECAP00000012443	ENSECAP00000000412	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.987
ACAT2	IDI1	ENSECAP00000012443	ENSECAP00000022536	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Isopentenyl-diphosphate delta isomerase 1.	0.500
ACAT2	MVD	ENSECAP00000012443	ENSECAP00000053047	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Mevalonate diphosphate decarboxylase.	0.542
ACAT2	MVK	ENSECAP00000012443	ENSECAP00000031677	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.681
DHDDS	FDPS	ENSECAP00000014011	ENSECAP00000053191	Alkyl transferase; Belongs to the UPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.947
DHDDS	FNTA	ENSECAP00000014011	ENSECAP00000017440	Alkyl transferase; Belongs to the UPP synthase family.	Farnesyltransferase, CAAX box, alpha.	0.966
DHDDS	FNTB	ENSECAP00000014011	ENSECAP00000052298	Alkyl transferase; Belongs to the UPP synthase family.	Protein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.	0.937
DHDDS	GGPS1	ENSECAP00000014011	ENSECAP00000015335	Alkyl transferase; Belongs to the UPP synthase family.	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family.	0.952
DHDDS	HMGCR	ENSECAP00000014011	ENSECAP00000042219	Alkyl transferase; Belongs to the UPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.415
DHDDS	IDI1	ENSECAP00000014011	ENSECAP00000022536	Alkyl transferase; Belongs to the UPP synthase family.	Isopentenyl-diphosphate delta isomerase 1.	0.864