(52 nodes) Metabolism of xenobiotics by cytochrome P450 network (Equus caballus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	AKR7A2	Aldo_ket_red domain-containing protein. (374 aa)
	LOC100050322	Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
	ALDH3B2	Aldehyde dehydrogenase 3 family member B2; Belongs to the aldehyde dehydrogenase family. (380 aa)
	AKR7L	Aldo_ket_red domain-containing protein. (341 aa)
	LOC100052993	Sulfotransferase; Belongs to the sulfotransferase 1 family. (286 aa)
	LOC111775200	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	CYP1A2	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa)
	LOC100146977	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
	CYP2A13	Uncharacterized protein; Belongs to the cytochrome P450 family. (529 aa)
	ALDH3A1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (470 aa)
	CYP1A1	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (524 aa)
	DHDH	Dihydrodiol dehydrogenase. (335 aa)
	F6WNE2_HORSE	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	LOC100068026	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
	LOC100066329	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	HSD11B1	Hydroxysteroid 11-beta dehydrogenase 1. (296 aa)
	GSTM3	Glutathione S-transferase. (225 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (560 aa)
	SRP9	Epoxide hydrolase 1. (491 aa)
	LOC100059533	Uncharacterized protein. (210 aa)
	GSTP1	Glutathione S-transferase pi 1. (210 aa)
	MGST1	Microsomal glutathione S-transferase 1-like protein. (155 aa)
	LOC100050329	Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa)
	LOC100630657	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (296 aa)
	LOC100146413	Uncharacterized protein. (526 aa)
	LOC100058329	Glutathione S-transferase. (218 aa)
	LOC100058290	Uncharacterized protein; Belongs to the GST superfamily. (432 aa)
	ENSECAP00000024986	Uncharacterized protein. (141 aa)
	UGT1A1	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
	GSTA4	Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (256 aa)
	ADH5	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (372 aa)
	ALDH3B1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (498 aa)
	CYP2F1	Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (504 aa)
	LOC100067994	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
	CBR3	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
	LOC100034175	Alcohol dehydrogenase S chain. (424 aa)
	HPGDS	Hematopoietic prostaglandin D synthase. (225 aa)
	LOC111772843	Uncharacterized protein. (375 aa)
	LOC100034242	Alcohol dehydrogenase E chain. (426 aa)
	LOC100066501	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	LOC100061690	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (296 aa)
	LOC100050266	Sulfotransferase; Belongs to the sulfotransferase 1 family. (284 aa)
	CYP2S1	Cytochrome P450 family 2 subfamily S member 1. (587 aa)
	LOC111772842	PKS_ER domain-containing protein. (380 aa)
	LOC100146938	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (232 aa)
	MGST2	Microsomal glutathione S-transferase 2. (224 aa)
	LOC111772845	PKS_ER domain-containing protein. (391 aa)
	GSTK1	Glutathione S-transferase kappa 1. (353 aa)
	UGT2A1	UDP glucuronosyltransferase family 2 member A1 complex locus; Belongs to the UDP-glycosyltransferase family. (704 aa)
	LOC100068041	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (329 aa)
	LOC100066444	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
	GSTT4	Glutathione S-transferase theta 4. (245 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH5	ALDH3A1	ENSECAP00000027421	ENSECAP00000008456	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.932
ADH5	ALDH3B1	ENSECAP00000027421	ENSECAP00000027431	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.933
ADH5	ALDH3B2	ENSECAP00000027421	ENSECAP00000002891	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Aldehyde dehydrogenase 3 family member B2; Belongs to the aldehyde dehydrogenase family.	0.933
ADH5	F6WNE2_HORSE	ENSECAP00000027421	ENSECAP00000014848	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.690
ADH5	GSTA4	ENSECAP00000027421	ENSECAP00000025356	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Glutathione S-transferase alpha 4; Belongs to the GST superfamily.	0.711
ADH5	GSTK1	ENSECAP00000027421	ENSECAP00000044213	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Glutathione S-transferase kappa 1.	0.704
ADH5	GSTM3	ENSECAP00000027421	ENSECAP00000016893	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Glutathione S-transferase.	0.743
ADH5	GSTP1	ENSECAP00000027421	ENSECAP00000018076	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Glutathione S-transferase pi 1.	0.684
ADH5	GSTT4	ENSECAP00000027421	ENSECAP00000050527	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Glutathione S-transferase theta 4.	0.677
ADH5	HPGDS	ENSECAP00000027421	ENSECAP00000033423	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Hematopoietic prostaglandin D synthase.	0.747
ADH5	LOC100050322	ENSECAP00000027421	ENSECAP00000002027	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Uncharacterized protein; Belongs to the GST superfamily.	0.677
ADH5	LOC100058290	ENSECAP00000027421	ENSECAP00000022530	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Uncharacterized protein; Belongs to the GST superfamily.	0.667
ADH5	LOC100058329	ENSECAP00000027421	ENSECAP00000021933	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Glutathione S-transferase.	0.689
ADH5	LOC100059533	ENSECAP00000027421	ENSECAP00000017624	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	Uncharacterized protein.	0.684
ADH5	LOC100066329	ENSECAP00000027421	ENSECAP00000015693	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.690
ADH5	LOC100066444	ENSECAP00000027421	ENSECAP00000049914	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.690
ADH5	LOC100066501	ENSECAP00000027421	ENSECAP00000034296	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.690
ADH5	LOC100067994	ENSECAP00000027421	ENSECAP00000029191	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.672
ADH5	LOC100068026	ENSECAP00000027421	ENSECAP00000015363	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.672
ADH5	LOC100068041	ENSECAP00000027421	ENSECAP00000049521	Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.672