STRINGSTRING
GAS6 GAS6 SHC1 SHC1 PIK3CD PIK3CD HRAS HRAS AKT2 AKT2 NF1 NF1 VEGFA VEGFA SHC2 SHC2 MAP2K2 MAP2K2 JAK2 JAK2 TGFA TGFA MAP2K1 MAP2K1 MET MET EGF EGF HGF HGF AXL AXL SRC SRC RPS6KB2 RPS6KB2 NRAS NRAS RPS6KB1 RPS6KB1 FGF2 FGF2 MAPK3 MAPK3 BAD BAD SHC4 SHC4 PIK3CA PIK3CA RPS6 RPS6 IL6 IL6 BAX BAX PTEN PTEN JAK1 JAK1 KRAS KRAS PDGFC PDGFC PRKCG PRKCG AKT3 AKT3 EIF4E2 EIF4E2 KDR KDR PIK3R1 PIK3R1 PLCG1 PLCG1 IGF1R IGF1R IL6R IL6R ARAF ARAF PIK3CB PIK3CB FOXO3 FOXO3 ERBB3 ERBB3 PDGFRB PDGFRB GSK3B GSK3B PIK3R2 PIK3R2 PDGFB PDGFB PDGFD PDGFD BCL2L1 BCL2L1 ERBB2 ERBB2 BRAF BRAF NRG2 NRG2 LOC100052122 LOC100052122 PLCG2 PLCG2 IGF1 IGF1 AKT1 AKT1 GAB1 GAB1 EIF4EBP1 EIF4EBP1 EGFR EGFR STAT3 STAT3 PRKCA PRKCA PRKCB PRKCB PDGFA PDGFA PDGFRA PDGFRA SOS2 SOS2 SHC3 SHC3 MAPK1 MAPK1 MTOR MTOR FGFR2 FGFR2 BCL2L11 BCL2L11 EIF4E EIF4E SOS1 SOS1 RAF1 RAF1 NRG1 NRG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAS6Growth arrest specific 6. (646 aa)
SHC1SHC adaptor protein 1. (584 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
NF1Neurofibromin 1. (3024 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (448 aa)
SHC2SHC adaptor protein 2. (579 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
TGFATransforming growth factor alpha. (221 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1412 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
SRCTyrosine-protein kinase. (551 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
BADBCL2 associated agonist of cell death. (167 aa)
SHC4SHC adaptor protein 4. (630 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
PTENPhosphatase and tensin homolog. (576 aa)
JAK1Tyrosine-protein kinase. (1141 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (368 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1358 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
IL6RInterleukin 6 receptor. (471 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (624 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
FOXO3Forkhead box O3. (671 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1339 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
PIK3R2Uncharacterized protein. (479 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (249 aa)
PDGFDPlatelet derived growth factor D. (566 aa)
BCL2L1BCL2 like 1. (245 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (793 aa)
NRG2Neuregulin 2. (923 aa)
LOC100052122Uncharacterized protein. (461 aa)
PLCG2Phosphoinositide phospholipase C. (1331 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
GAB1GRB2 associated binding protein 1. (771 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (210 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (569 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
SHC3SHC adaptor protein 3. (591 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
FGFR2Fibroblast growth factor receptor. (887 aa)
BCL2L11BCL2 like 11. (289 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1613 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
NRG1Neuregulin 1. (712 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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