STRINGSTRING
GPER1 GPER1 LOC100050675 LOC100050675 CDKN2C CDKN2C SHC1 SHC1 MAPK11 MAPK11 DLL3 DLL3 PIK3CD PIK3CD HRAS HRAS MAPK8 MAPK8 AKT2 AKT2 MED1 MED1 SHC2 SHC2 LOC100058496 LOC100058496 MAP2K2 MAP2K2 ADCY5 ADCY5 MAP2K1 MAP2K1 SRC SRC RPS6KB2 RPS6KB2 NOTCH4 NOTCH4 DLL4 DLL4 MMP9 MMP9 ADCY4 ADCY4 JAG1 JAG1 NRAS NRAS FOS FOS RPS6KB1 RPS6KB1 DLL1 DLL1 MAPK3 MAPK3 MAPK14 MAPK14 BAD BAD SHC4 SHC4 PIK3CA PIK3CA ABCB11 ABCB11 BAX BAX ADCY2 ADCY2 MAPK12 MAPK12 BIK BIK KRAS KRAS AKT3 AKT3 PIK3R1 PIK3R1 CDKN1A CDKN1A NOTCH3 NOTCH3 IGF1R IGF1R ESR1 ESR1 NOTCH1 NOTCH1 CDKN1B CDKN1B E2F1 E2F1 E2F2 E2F2 JUN JUN ARAF ARAF ADCY9 ADCY9 PIK3CB PIK3CB ADCY8 ADCY8 ESR2 ESR2 CDK4 CDK4 ADCY1 ADCY1 PIK3R2 PIK3R2 HBEGF HBEGF E2F3 E2F3 PTK2 PTK2 ADCY6 ADCY6 MMP2 MMP2 CCND1 CCND1 ERBB2 ERBB2 MDM2 MDM2 ADCY3 ADCY3 BRAF BRAF PRKACA PRKACA LOC100052122 LOC100052122 TP53 TP53 IGF1 IGF1 AKT1 AKT1 MAPK9 MAPK9 EGFR EGFR ADCY7 ADCY7 SP1 SP1 RB1 RB1 PRKACB PRKACB JAG2 JAG2 MAPK13 MAPK13 NCOA3 NCOA3 NCOR1 NCOR1 NOTCH2 NOTCH2 SOS2 SOS2 SHC3 SHC3 MAPK1 MAPK1 CARM1 CARM1 MAPK10 MAPK10 MTOR MTOR SOS1 SOS1 RAF1 RAF1 CDKN2A CDKN2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
LOC100050675Uncharacterized protein. (250 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
SHC1SHC adaptor protein 1. (584 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
DLL3Delta like canonical Notch ligand 3. (619 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
SHC2SHC adaptor protein 2. (579 aa)
LOC100058496CARM1 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (463 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SRCTyrosine-protein kinase. (551 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
NOTCH4Notch receptor 4. (2021 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
MMP9Matrix metallopeptidase 9. (714 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
BADBCL2 associated agonist of cell death. (167 aa)
SHC4SHC adaptor protein 4. (630 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ABCB11ATP binding cassette subfamily B member 11. (1321 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
MAPK12Mitogen-activated protein kinase. (365 aa)
BIKUncharacterized protein. (226 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
NOTCH3Notch receptor 3. (2458 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (608 aa)
NOTCH1Notch receptor 1. (2581 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
E2F1E2F transcription factor 1. (436 aa)
E2F2E2F transcription factor 2. (549 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (624 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
ESR2Estrogen receptor 2. (550 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
PIK3R2Uncharacterized protein. (479 aa)
HBEGFHeparin binding EGF like growth factor. (390 aa)
E2F3E2F transcription factor 3. (546 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1093 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1206 aa)
MMP2Matrix metallopeptidase 2. (659 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (491 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (793 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
LOC100052122Uncharacterized protein. (461 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
MAPK9Mitogen-activated protein kinase. (446 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
SP1Sp1 transcription factor. (787 aa)
RB1RB transcriptional corepressor 1. (965 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1240 aa)
MAPK13Mitogen-activated protein kinase. (421 aa)
NCOA3Nuclear receptor coactivator. (1427 aa)
NCOR1Nuclear receptor corepressor 1. (2436 aa)
NOTCH2Notch receptor 2. (2471 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
SHC3SHC adaptor protein 3. (591 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (608 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1613 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (214 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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