STRINGSTRING
KITLG KITLG RAPGEF5 RAPGEF5 CSF1R CSF1R REL REL KSR2 KSR2 ARF6 ARF6 GNG10 GNG10 RAP1B RAP1B SHC1 SHC1 EFNA4 EFNA4 LOC100049912 LOC100049912 CALML3 CALML3 RASA1 RASA1 PLA2G5 PLA2G5 PLA2G4D PLA2G4D PIK3CD PIK3CD BRAP BRAP GNB4 GNB4 ELK1 ELK1 HRAS HRAS NTF4 NTF4 MAPK8 MAPK8 GNG14 GNG14 AKT2 AKT2 EPHA2 EPHA2 CALM1 CALM1 RASAL3 RASAL3 ANGPT4 ANGPT4 NF1 NF1 VEGFA VEGFA SHC2 SHC2 MAP2K2 MAP2K2 INSR INSR RASAL1 RASAL1 PLA2G12B PLA2G12B NGF NGF VEGFB VEGFB RASGRP1 RASGRP1 FGF21 FGF21 TGFA TGFA MAP2K1 MAP2K1 MET MET PLA2G2A PLA2G2A EGF EGF ZAP70 ZAP70 HGF HGF RASA2 RASA2 EFNA5 EFNA5 GNG3 GNG3 RASSF1 RASSF1 GNB3 GNB3 SHOC2 SHOC2 PLA2G4F PLA2G4F KIT KIT NRAS NRAS RELA RELA FGF10 FGF10 RALB RALB RASGRF1 RASGRF1 FGF2 FGF2 MAPK3 MAPK3 BAD BAD SHC4 SHC4 PLD2 PLD2 PLA2G12A PLA2G12A PIK3CA PIK3CA NFKB1 NFKB1 FGF7 FGF7 FGF5 FGF5 GNGT2 GNGT2 ANGPT2 ANGPT2 PLA2G2E PLA2G2E PLA2G10 PLA2G10 FASLG FASLG RALA RALA ANGPT1 ANGPT1 TEK TEK GNB2 GNB2 PAK6 PAK6 NGFR NGFR GNG13 GNG13 PAK1 PAK1 FGF9 FGF9 KRAS KRAS PDGFC PDGFC PRKCG PRKCG PLAAT3 PLAAT3 AKT3 AKT3 KDR KDR PIK3R1 PIK3R1 PAK2 PAK2 IKBKG IKBKG FGF1 FGF1 PLA2G2F PLA2G2F FGF23 FGF23 TBK1 TBK1 TIAM1 TIAM1 LAT LAT EFNA1 EFNA1 PLCG1 PLCG1 CALML4 CALML4 IGF1R IGF1R FGF6 FGF6 RALGDS RALGDS PLCE1 PLCE1 GRIN2B GRIN2B RAB5B RAB5B RASGRP2 RASGRP2 LOC100060748 LOC100060748 GNG11 GNG11 PIK3CB PIK3CB NTF3 NTF3 INS INS GNG8 GNG8 PTPN11 PTPN11 FGF17 FGF17 GRIN1 GRIN1 PDGFRB PDGFRB RAB5C RAB5C PLA2G3 PLA2G3 FLT4 FLT4 FLT1 FLT1 PIK3R2 PIK3R2 RASGRP4 RASGRP4 LOC100056032 LOC100056032 FGF19 FGF19 PDGFB PDGFB CDC42 CDC42 RRAS RRAS LOC111767719 LOC111767719 PDGFD PDGFD PAK5 PAK5 LOC111772100 LOC111772100 LOC100053989 LOC100053989 BCL2L1 BCL2L1 GNG4 GNG4 RASGRP3 RASGRP3 ENSECAP00000027749 ENSECAP00000027749 FGF18 FGF18 GNGT1 GNGT1 PLA2G4A PLA2G4A FGF16 FGF16 FGF22 FGF22 IKBKB IKBKB KSR1 KSR1 STK4 STK4 NTRK2 NTRK2 PRKACA PRKACA PLA2G2D PLA2G2D LOC100052122 LOC100052122 ABL1 ABL1 CALML5 CALML5 GNG5 GNG5 PLCG2 PLCG2 GNG7 GNG7 PLA2G4E PLA2G4E ETS2 ETS2 VEGFD VEGFD IGF1 IGF1 EFNA2 EFNA2 AKT1 AKT1 GAB1 GAB1 NTRK1 NTRK1 ETS1 ETS1 MAPK9 MAPK9 EXOC2 EXOC2 EGFR EGFR RAC1 RAC1 BDNF BDNF RASA3 RASA3 PRKCA PRKCA GAB2 GAB2 LOC102149416 LOC102149416 RAC2 RAC2 RHOA RHOA CHUK CHUK PLA2G1B PLA2G1B VEGFC VEGFC FGF20 FGF20 PLA2G6 PLA2G6 FGF4 FGF4 FGF3 FGF3 PRKACB PRKACB MRAS MRAS RAB5A RAB5A RASGRF2 RASGRF2 JMJD7 JMJD7 PRKCB PRKCB LOC106783094 LOC106783094 SYNGAP1 SYNGAP1 PDGFA PDGFA RGL1 RGL1 PDGFRA PDGFRA PLD1 PLD1 GNB1 GNB1 GNG12 GNG12 ENSECAP00000045695 ENSECAP00000045695 SOS2 SOS2 FGFR1 FGFR1 SHC3 SHC3 LOC102150685 LOC102150685 GRIN2A GRIN2A MAPK1 MAPK1 MAPK10 MAPK10 PGF PGF ADPRH ADPRH RASSF5 RASSF5 FOXO4 FOXO4 FGFR2 FGFR2 LOC106780978 LOC106780978 GNB5 GNB5 GNG2 GNG2 RASAL2 RASAL2 HTR7 HTR7 IGF2 IGF2 FLT3 FLT3 FGFR4 FGFR4 SOS1 SOS1 LOC102148588 LOC102148588 RAF1 RAF1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (303 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (731 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (968 aa)
RELREL proto-oncogene, NF-kB subunit. (596 aa)
KSR2Kinase suppressor of ras 2. (950 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
RAP1BRas-related protein Rap-1b-like protein. (184 aa)
SHC1SHC adaptor protein 1. (584 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (204 aa)
LOC100049912Uncharacterized protein. (184 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
RASA1RAS p21 protein activator 1. (1041 aa)
PLA2G5Phospholipase A(2). (158 aa)
PLA2G4DPhospholipase A2. (817 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BRAPBRCA1 associated protein. (592 aa)
GNB4G protein subunit beta 4. (340 aa)
ELK1ETS transcription factor ELK1. (432 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
EPHA2EPH receptor A2. (975 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (336 aa)
RASAL3RAS protein activator like 3. (1029 aa)
ANGPT4Angiopoietin 4. (497 aa)
NF1Neurofibromin 1. (3024 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (448 aa)
SHC2SHC adaptor protein 2. (579 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
RASAL1RAS protein activator like 1. (926 aa)
PLA2G12BPhospholipase A2 group XIIB. (195 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
TGFATransforming growth factor alpha. (221 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1412 aa)
PLA2G2APhospholipase A(2). (144 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
RASA2RAS p21 protein activator 2. (966 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RASSF1Ras association domain family member 1. (344 aa)
GNB3G protein subunit beta 3. (340 aa)
SHOC2SHOC2 leucine rich repeat scaffold protein. (582 aa)
PLA2G4FPhospholipase A2. (849 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1084 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
RALBRAS like proto-oncogene B. (206 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1257 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
BADBCL2 associated agonist of cell death. (167 aa)
SHC4SHC adaptor protein 4. (630 aa)
PLD2Phospholipase. (933 aa)
PLA2G12APhospholipase A2 group XIIA. (182 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFKB1Nuclear factor kappa B subunit 1. (1049 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF5Fibroblast growth factor 5. (280 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (86 aa)
ANGPT2Angiopoietin 2. (496 aa)
PLA2G2EPhospholipase A(2). (142 aa)
PLA2G10Phospholipase A(2). (160 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (283 aa)
RALARAS like proto-oncogene A. (227 aa)
ANGPT1Angiopoietin 1. (498 aa)
TEKTEK receptor tyrosine kinase. (1153 aa)
GNB2G protein subunit beta 2. (340 aa)
PAK6Non-specific serine/threonine protein kinase. (680 aa)
NGFRNerve growth factor receptor. (435 aa)
GNG13G protein subunit gamma 13. (67 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (368 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PLAAT3Phospholipase A and acyltransferase 3. (162 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1358 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PLA2G2FPhospholipase A(2). (210 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
TBK1TANK binding kinase 1. (729 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
LATLinker for activation of T cells. (238 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (317 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
CALML4Calmodulin like 4. (197 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RALGDSUncharacterized protein. (916 aa)
PLCE1Phosphoinositide phospholipase C. (2299 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1497 aa)
RAB5BRAB5B, member RAS oncogene family. (215 aa)
RASGRP2RAS guanyl releasing protein 2. (608 aa)
LOC100060748Uncharacterized protein. (1033 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (240 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (1004 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
RAB5CRAB5C, member RAS oncogene family. (248 aa)
PLA2G3Phospholipase A2 group III. (513 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1366 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1336 aa)
PIK3R2Uncharacterized protein. (479 aa)
RASGRP4RAS guanyl releasing protein 4. (724 aa)
LOC100056032Ras-GEF domain-containing protein. (645 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (249 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
RRASRAS related. (220 aa)
LOC111767719Ig-like domain-containing protein. (187 aa)
PDGFDPlatelet derived growth factor D. (566 aa)
PAK5Non-specific serine/threonine protein kinase. (718 aa)
LOC111772100Ig-like domain-containing protein. (173 aa)
LOC100053989LRAT domain-containing protein. (287 aa)
BCL2L1BCL2 like 1. (245 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (164 aa)
RASGRP3RAS guanyl releasing protein 3. (692 aa)
ENSECAP00000027749Phospholipase A(2). (83 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PLA2G4ACytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (749 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (770 aa)
KSR1Kinase suppressor of ras 1. (761 aa)
STK4Serine/threonine kinase 4. (493 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
PLA2G2DPhospholipase A(2). (145 aa)
LOC100052122Uncharacterized protein. (461 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
CALML5Calmodulin like 5. (149 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (341 aa)
PLCG2Phosphoinositide phospholipase C. (1331 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PLA2G4EPhospholipase A2. (864 aa)
ETS2ETS proto-oncogene 2, transcription factor. (665 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (214 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
GAB1GRB2 associated binding protein 1. (771 aa)
NTRK1Tyrosine-protein kinase receptor. (880 aa)
ETS1ETS proto-oncogene 1, transcription factor. (503 aa)
MAPK9Mitogen-activated protein kinase. (446 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (979 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
RAC1Rac family small GTPase 1. (221 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (299 aa)
RASA3RAS p21 protein activator 3. (869 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
GAB2GRB2 associated binding protein 2. (708 aa)
LOC102149416Ras-GEF domain-containing protein. (622 aa)
RAC2Rac family small GTPase 2. (192 aa)
RHOATransforming protein RhoA-like protein. (193 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
PLA2G1BPhospholipase A2 isoform 2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules; Belongs to the phospholipase A2 family. (151 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PLA2G6Phospholipase A2 group VI. (1134 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (231 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
RAB5ARAB5A, member RAS oncogene family. (215 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1313 aa)
JMJD7Phospholipase A2. (849 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
LOC106783094Ig-like domain-containing protein. (229 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1349 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (569 aa)
RGL1Ral guanine nucleotide dissociation stimulator like 1. (803 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PLD1Phospholipase. (1189 aa)
GNB1G protein subunit beta 1. (360 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ENSECAP00000045695LRAT domain-containing protein. (137 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
FGFR1Fibroblast growth factor receptor. (877 aa)
SHC3SHC adaptor protein 3. (591 aa)
LOC102150685Ras-GEF domain-containing protein. (571 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1452 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (210 aa)
ADPRHADP-ribosylarginine hydrolase. (790 aa)
RASSF5Ras association domain family member 5. (422 aa)
FOXO4Forkhead box O4. (529 aa)
FGFR2Fibroblast growth factor receptor. (887 aa)
LOC106780978Ras-GEF domain-containing protein. (703 aa)
GNB5G protein subunit beta 5. (395 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (108 aa)
RASAL2RAS protein activator like 2. (1419 aa)
HTR75-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (475 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (450 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1020 aa)
FGFR4Fibroblast growth factor receptor. (855 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1613 aa)
LOC102148588Ras-GEF domain-containing protein. (438 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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